CAS: 23567-25-1; (2R,3R,4R,5S)-2,3,4,5,6-Pentahydroxyhexanal

相似化合物

10030-80-5 50-99-7 59-23-4

上下游产品

mannitol para-xylene water L-talonic acid γ-lactone5-hydroxymethyl-2-furfuraldehyde glycolic Acid LACTIC ACID mannitol

📜在 Palladium Dihydroxide 氢气体系中,用 四氢呋喃,水 用作溶剂,化学反应生成L(-)-塔洛糖
参考文献:从常见的手性结构单元到醛糖己糖的新的聚合路线.
标题:从常见的手性结构单元到醛糖己糖的新的聚合路线.
摘要:[文本中的反应]从常见的环己酸手性结构单元开始,开发了一种非对映控制的途径来合成8个醛己糖.
Doi:10.1021/ol015733I

专利信息

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:US-5627270-A
优先权日:1991-12-13
标题:Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
发明人：KAHNE DANIEL E; KAHNE SUZANNE W; SOFIA MICHAEL J; HATZENBUHLER NICOLE T
权利人:UNIV PRINCETON; TRANSCELL TECHNOLOGIES INC
摘要:Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.

专利号:US-5693769-A
优先权日:1991-12-13
标 题 :Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
发明人：KAHNE DANIEL EVAN; KAHNE SUZANNE WALKER
权利人:TRANSCELL TECHNOLOGIES INC; UNIV PRINCETON
摘要:Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:EP-4076533-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins

专利号:CA-3164962-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins