CAS: 22150-76-1; 2-Amino-6-((1R,2S)-1,2-Dihydroxypropyl)Pteridin-4(1H)-One

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📜5-Deoxy-L-Ribose Phenylhydrazone置于4-二甲氨基吡啶,高氯酸,四丁基溴化铵,Potassium Hydroxide体系中,用 甲醇,水,乙酸乙酯 用作溶剂,化学反应 59.0H,反应生成L-生物蝶呤
参考文献: Novel Process For The Preparation Of Sapropterin Dihydrochloride And Its Key Intermediate,L-Biopterin[fr] Nouveau Procédé De Préparation De Dichlorhydrate De Saproptérine Et De Son Intermédiaire Clé,La L-Bioptérine
标题: Novel Process For The Preparation Of Sapropterin Dihydrochloride And Its Key Intermediate,L-Biopterin[fr] Nouveau Procédé De Préparation De Dichlorhydrate De Saproptérine Et De Son Intermédiaire Clé,La L-Bioptérine
摘要:本发明涉及一种新型用于制备化学式(1)的硫酚托普特林二盐酸盐和其关键中间体化学式(2)的l-赤鼻酚的工艺.该现有工艺是一种简单且经济可行的工艺,用于商业生产化学式(1)的硫酚托普特林二盐酸盐和其关键中间体化学式(2)的l-赤鼻酚.

专利信息

专利号:EP-1689880-B1
优先权日:2003-11-26
标 题:Detection of no by using guanylyl cyclase and cgmp production as a readout system
发明人：BUETTNER FRANK
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A method for measuring nitric oxide synthase activity, characterized in the method comprises; (a) providing a solution comprising a nitric oxide synthase and a suitable substrate under conditions which allow synthesis of nitric oxide; (b) adding guanylyl cyclase and GTP under conditions which allow synthesis of cGMP; (c) measuring cGMP.

专利号:US-8809553-B2
优先权日:2010-06-15
标题:Process for the preparation of pteridine derivatives
发明人：ATTOLINO EMANUELE; MICHIELETTI MARIO; ROSSI DAVIDE; ALLEGRINI PIETRO
权利人:ATTOLINO EMANUELE; MICHIELETTI MARIO; ROSSI DAVIDE; ALLEGRINI PIETRO; DIPHARMA FRANCIS SRL
摘要:The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.

专利号:US-5401844-A
优先权日:1983-04-11
标 题 :Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted-tetrahydropteridines
发明人：AYLING JUNE E; BAILEY STEVEN W
权利人:UNIV SOUTH ALABAMA
摘要:6-[2'-Amino-2',2'-disubstituted-ethylamino]-pyrimidines of the structure: ##STR1## in which X=H, NH 2 or NO 2 , which are novel intermediates in the synthesis of quinoid 6,6-disubstituted-dihydro- and 6,6-disubstituted-tetrahydro-pteridines, are claimed.

专利号:US-6153615-A
优先权日:1991-12-26
标 题 :Blocking induction of tetrahydrobioterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonists are administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylactic or curative effect for endotoxin- or cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension). The tetrahydrobiopterin synthesis antagonist may be administered with α 1 -adrenergic agonist or with nitric oxide synthase inhibitor. The tetrahydrobiopterin synthesis antagonists are also administered to attenuate inflammation caused by induced nitric oxide production in immune cells. Unwanted counterproductive or side effects can be eliminated or ameliorated by administration additionally of levodopa with or without carbidopa and L-5-hydroxytryptophane.

专利号:US-6274581-B1
优先权日:1991-12-26
标 题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonist are administered to inhibit nitric oxide synthesis from arginine in vascular smooth muscle cells in a subject in need of such inhibition (e.g. for prophylactic or curative effect for cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension).

专利号:US-5874433-A
优先权日:1993-11-29
标题 :Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
发明人：GROSS STEVEN S
权利人:CORNELL RES FOUNDATION INC
摘要:Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as 1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine or, 4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine) or tetrahydropterin analog which does not replace tetrahydrobiopterin as a substrate for nitric oxide synthase such as (6R,S)-6,7-dimethyl-tetrahydropterin or (6R,S)-tetrahydrofolic acid or 2,4-diamino-, 2,6-diamino, or 4,6-diamino mono- or disubstituted pyrimidines or the corresponding pyrimidine-3-oxides such as 2,4-diamino-6-(diethylamino)pyrimidine, 2,4-diamino-6-piperidino-pyrimidine-3-oxide, 2,4-diamino-6-hydroxypyrimidine, 4,6-diamino-2-hydroxypyrimidine or 2,5-diamino-4,6-dihydroxypyrimidine is administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylaxis or treatment of cytokine- or endotoxin-induced hypotension (e.g., septic shock). The latter two types are advantageously administered with nitric oxide synthase inhibitors (concurrent therapy) or to potentiate the effect of α 1 -adrenergic agonists in the prophylaxis or treatment of induced hypotension.