CAS: 17609-52-8; (R)-2-(((Benzyloxy)Carbonyl)Amino)-2-Phenylacetic Acid

相似化合物

53990-33-3 102410-65-1 111524-95-9

上下游产品

CAS号394210-43-6 benzyl 2,5-diox... | CAS号591-51-5 苯基锂 | CAS号501-53-1 氯甲酸苄酯 | CAS号193091-62-2 (E)-(R)-O-(1-ph... | CAS号14441-08-8 (S)-N-Z-3-AMINO... | CAS号83649-47-2 (S)-3-氨基-3- 苯基丙酸盐酸盐 | CAS号153837-28-6 (R)-(-)-N-新戊基-1... | CAS号136329-39-0 (R)-(-)-N-甲基-1-... | CAS号3412-49-5 (R)-4-苯基氧氮杂环戊烷-... | CAS号129157-10-4 (R)-(+)-N-异丙基-1... | CAS号439088-73-0 (R)-2-(2-(((苄氧基...

2-氨基-2-苯基乙酸置于四(三苯基膦)钯 吗啉,N-甲基吗啉,Hydroquinidine Anthraquinone-1,4-Diyl Diether,4 A Molecular Sieve体系中,用 四氢呋喃,乙醚 用作溶剂,化学反应 4.17H,反应生成苄氧羰酰基苯甘氨酸
参考文献:快速,室温动态动力学分辨率的发展,以有效地不对称合成α-芳基氨基酸.
标题:快速,室温动态动力学分辨率的发展,以有效地不对称合成α-芳基氨基酸.
摘要:[反应:见正文]在室温下,外消旋α-芳基unca具有双功能催化修饰金鸡纳生物碱的快速,高效和一般动态动力学拆分(dkr).该dkr导致了高度对映选择性催化方法的发展,该方法可用于实际合成范围广泛的α-芳基和α-杂芳基氨基酸,Ee含量为89-92%,外消旋unca的收率为86-95%.
Doi:10.1021/ol026660L

专利信息

专利号:US-3732199-A
优先权日:1971-03-15
标 题 :Peptide synthesis
发明人：SCHWARZ J
权利人:SQUIBB & SONS INC
摘要:IMPROVEMENT IN THE SYNTHESIS OF PEPTIDES INVOLVING THE FORMATION OF NOVEL ACTIVE INTERMEDIATES. THESE ACTIVE INTERMEDIATES ARE FORMED BY REACTION AT LOWERED TEMPERATRES OF AN IMIDYL HALIDE WITH THE TERTIARY AMMONIUM SALT OF THE ACID MOIETY OF AN AMINO ACID OR PEPTIDE. THE INTERMEDIATE THUS FORMED IS THEN REACTED WITH THE AMINO MOIETY OF THE AMINO ACID OR PEPTIDE TO BE COUPLED, THUS FORMING THE DESIRED PEPTIDE OR POLYPEPTIDE.

专利号:US-4271172-A
优先权日:1979-06-25
标 题 :6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, antibacterial compositions thereof and method of use thereof
发明人：RODRIGUEZ LUDOVIC; LECLERCQ JACQUES; YKMAN PIERRE; COSSEMENT ERIC
权利人:UCB SA
摘要:6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, salts and esters thereof of the formula ##STR1## wherein R 1 is hydrogen, benzyl or an alkali metal or ammonium ion and R 2 is methyl, phenyl or benzyl and process for preparing the same. n These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum. Therefore, they are useful as antibacterials agents and as therapeutic agents for humans and for animals in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

专利号:US-4171439-A
优先权日:1975-04-11
标 题 :Antibacterial analogs of isocephalosporins
发明人：CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo or hydroxyl and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4112230-A
优先权日:1975-04-11
标题 :Δ2,3 -1,4 Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：MENARD MARCEL; LIM GARY M F; CONWAY TERRY T
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-4166906-A
优先权日:1975-04-11
标题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is hydroxyl esterified with a sulfonic acid residue and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group of the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-3994883-A
优先权日:1972-12-27
标 题 :Penicillin and cephalosporin intermediates
发明人：BORREVANG POUL; GUDDAL ERLING; PETERSEN HENNING BORGE; FAARUP PETER; NIELSEN JORGEN ILUM
权利人:NOVO INDUSTRI AS
摘要:Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.