CAS: 144702-27-2; 4'-((1,7'-Dimethyl-2'-Propyl-1H,3'H-[2,5'-Bibenzo[d]Imidazol]-3'-yl)Methyl)-[1,1'-Biphenyl]-2-Carbonitrile

该化合物是合成中间体,产自Telmisartan, 血管受体二号,该化合物主要用于药物研发,作为合成Telmisartan及其类似物的前体,其关键的结构改造-脱carboxylation和cyano替代,加强了其在药用化学应用中的回旋性和多功能.该化合物因其高纯度和稳定性而备受珍视,适合精确的合成路径.研究人员利用这一中间体探索具有潜在治疗作用的新衍生物,特别是在心血管药物开发中.其定义明确的化学特性确保实验室环境的一贯性,支持高效的扩展过程.

英文名称4'-((1,7'-Dimethyl-2'-Propyl-1H,3'H-[2,5'-Bibenzo[d]Imidazol]-3'-yl)Methyl)-[1,1'-Biphenyl]-2-Carbonitrile
中文名称4'-[(1,4'-二甲基-2'-丙基[2,6'-联-1H-苯并咪唑]-1'-基)甲基]联苯-2-甲腈
IUPAC名称4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
其它别名[1,1'-Biphenyl]-2-Carbonitrile,4'-[[1,4'-Dimethyl-2'-; 2-Descarboxy-2-Cyano Telmisartan; Telmisartan Impurity G; Telmisartan Ep Impurity G; [1,1'-Biphenyl]-2-Carbonitrile, 4'-[(1,4'-Dimethyl-2'-Propyl[2,6'-Bi-1H-Benzimidazol]-1'-yl) Methyl]-; [1,1'-Biphenyl]-2-Carbonitrile,4'-[(1,4'-Dimethyl -2'-Propyl [2,6”-Bi; [1,1'-Biphenyl]-2-Carbonitrile,4'-[(1,4'-Dimethyl -2'-Propyl [2,6”-Bi -1H-Benzimidazole ] -1'-yl) Methyl ] – (1,1-Biphenyl)-2-Carbonitrile; Telmisartan Impurity 7(Telmisartan Ep Impurity G)
CAS编号144702-27-2
MFCD编号:MFCD21496234
FDA UNII编号:A8M0GXG1XV
分子式:C33H29N5
分子量:495.63
产品CID: 681226
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: XIEVZYAEXURSHX-UHFFFAOYSA-N
InChI=1S/C33H29N5/c1-4-9-31-36-32-22(2)18-26(33-35-28-12-7-8-13-29(28)37(33)3)19-30(32)38(31)21-23-14-16-24(17-15-23)27-11-6-5-10-25(27)20-3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数6.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338-
安全声明H303+H313+H333

上下游产品

合成工艺路线路线简述

3-甲基-4-丁酰氨基-5-硝基苯甲酸甲酯置于镍氯化亚砜,水,氢气,对甲苯磺酸,三乙胺,Potassium Hydroxide,Sodium Hydroxide体系中,用甲醇,二氯甲烷,N,N-二甲基甲酰胺,甲苯用作溶剂,5.0~85.0 °C,441.31 Kpa 条件下,反应 6.5H,反应生成4'-[(1,4'-二甲基-2'-丙基[2,6'-联-1H-苯并咪唑]-1'-基)甲基]联苯-2-甲腈
参考文献: Novel Intermediates And Method For Synthesis Of 4'-[(1,4'-Dimethyl-2'-Propyl-[2,6'-Bi-1Hbenzimidazol]-L-yl)Methyl]-1,1-Biphenyl]-2-Carboxylic Acid.[fr] Nouveaux Intermédiaires Et Procédé De Synthèse De 4'-[(1,4'-Diméthyl-2'-Propyl-[2,6'-Bi-1Hbenzimidazol]-L-yl)Méthyl]-1,1-Biphényl]-2-Acide Carboxylique
标题: Novel Intermediates And Method For Synthesis Of 4'-[(1,4'-Dimethyl-2'-Propyl-[2,6'-Bi-1Hbenzimidazol]-L-yl)Methyl]-1,1-Biphenyl]-2-Carboxylic Acid.[fr] Nouveaux Intermédiaires Et Procédé De Synthèse De 4'-[(1,4'-Diméthyl-2'-Propyl-[2,6'-Bi-1Hbenzimidazol]-L-yl)Méthyl]-1,1-Biphényl]-2-Acide Carboxylique