CAS: 13380-36-4; (2S,4R)-1-Methyl-4-Propylpyrrolidine-2-Carboxylic Acid

该化合物是一种非蛋白性活性活性衍生物,其特点是其独特的立体化学和功能性组别修改.四点的变异配置,加上丙基替代体,提高了符合性刻板性,使其在peptide设计和医药化学中具有价值.一甲基组别进一步限制了主干弹性,改善了代谢稳定性和生物利用率.这一复合物在受限的peptids和peptimics的合成中特别有用,在这种合成中,受控的立体化学和侧链互动至关重要.其结构特征还有利于对酶抑制和受体约束的研究.高纯度和定义明确的立体化学确保研究应用中的再生能力.

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58123-62-9 6734-79-8 1378252-71-1

上下游产品

lincomycin clindamycin phosphate

合成工艺路线路线简述

    📜林可霉素置于sodium Hydroxide体系中,化学反应 22.0H,反应生成(反式)-4-丙基-1-甲基-L-脯氨酸,α-Methylthiolincosaminide
    参考文献:Biosynthesis Of The Lincomycins. 1. Studies Using Stable Isotopes On The Biosynthesis Of The Propyl-And Ethyl-L-Hygric Acid Moieties Of Lincomycins A And B
    标题:Biosynthesis Of The Lincomycins. 1. Studies Using Stable Isotopes On The Biosynthesis Of The Propyl-And Ethyl-L-Hygric Acid Moieties Of Lincomycins A And B
    摘要:
    Doi:10.1021/ja00337A038

    海关参考信息

    专利信息


    专利号:US-7199105-B2
    优先权日:2002-08-15
    标 题:Lincomycin derivatives possessing antibacterial activity
    发明人:LEWIS JASON G; PATEL DINESH V; ANANDAN SAMPATH KUMAR; GORDEEV MIKHAIL F
    权利人:VICURON PHARM INC
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

    专利号:US-7164011-B2
    优先权日:2002-08-15
    标题:Lincomycin derivatives possessing antibacterial activity
    发明人:LEWIS JASON; PATEL DINESH V; ANANDAN SAMPATH K; GORDEEV MIKHAIL F
    权利人:VICURON PHARM INC
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1038/s41929-023-00971-y
    摘要:Mori T, Kadlcik S, Lyu S, Kamenik Z, Sakurada K, Mazumdar A, Wang H, Janata J, Abe I. Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics. Nat Catal. 2023 Jun 12;6(6):531–42. doi: 10.1038/s41929-023-00971-y.
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