📜林可霉素置于sodium Hydroxide体系中,化学反应 22.0H,反应生成(反式)-4-丙基-1-甲基-L-脯氨酸,α-Methylthiolincosaminide 参考文献:Biosynthesis Of The Lincomycins. 1. Studies Using Stable Isotopes On The Biosynthesis Of The Propyl-And Ethyl-L-Hygric Acid Moieties Of Lincomycins A And B 标题:Biosynthesis Of The Lincomycins. 1. Studies Using Stable Isotopes On The Biosynthesis Of The Propyl-And Ethyl-L-Hygric Acid Moieties Of Lincomycins A And B 摘要: Doi:10.1021/ja00337A038
专利号:US-7199105-B2 优先权日:2002-08-15 标 题:Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON G; PATEL DINESH V; ANANDAN SAMPATH KUMAR; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-7164011-B2 优先权日:2002-08-15 标题:Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON; PATEL DINESH V; ANANDAN SAMPATH K; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
参考文献:10.1038/s41929-023-00971-y 摘要:Mori T, Kadlcik S, Lyu S, Kamenik Z, Sakurada K, Mazumdar A, Wang H, Janata J, Abe I. Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics. Nat Catal. 2023 Jun 12;6(6):531–42. doi: 10.1038/s41929-023-00971-y.