CAS: 1202160-40-4; (E)-2-Cyano-3-(4-Hydroxy-3-Methoxy-5-Nitrophenyl)Acrylic Acid

英文名称(E)-2-Cyano-3-(4-Hydroxy-3-Methoxy-5-Nitrophenyl)Acrylic Acid
中文名称恩他卡朋杂质4
CAS编号1202160-40-4
分子式:C11H8N2O6分子量:264.19
产品CID: 268698
产品分类有机原料 → 苯丙烷和聚酮 → 肉桂酸及其衍生物

相似结构搜索
InChIKey: DWARFKWNFUAUGA-FARCUNLSSA-N
1S/C11H8N2O6/c1-19-9-4-6(2-7(5-12)11(15)16)3-8(10(9)14)13(17)18/h2-4,14H,1H3,(H,15,16)/b7-2+
计算化学: 氢键受体数7.0氢键供体数2.0可旋转键数3.0

MSDS等安全信息

警示词warning
危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

上下游产品

isonitrovanillin cyanoacetic acid

合成工艺路线路线简述

合成目标产物 Entacapone Impurity 4 主要起始原料 5-Nitrovanillin And Cyanoacetic Acid
(文献来源)合成步骤主要原料 5-Nitrovanillin 和 Cyanoacetic Acid

📜5-硝基香兰素,氰乙酸置于2,2',2''-次氮基三乙醇乙酸盐体系中,化学反应 1.0H,以82%的收率获得恩他卡朋杂质4
参考文献:Co2 Absorbing Cost-Effective Ionic Liquid For Synthesis Of Commercially Important Alpha Cyanoacrylic Acids: A Safe Process For Activation Of Cyanoacetic Acid
标题:Co2 Absorbing Cost-Effective Ionic Liquid For Synthesis Of Commercially Important Alpha Cyanoacrylic Acids: A Safe Process For Activation Of Cyanoacetic Acid
摘要:一种具有成本效益且能吸收二氧化碳的离子液体三-(2-羟乙基)铵乙酸盐在knoevenagel缩合反应中表现出多重作用.它作为一种环境友好的溶剂,作为反应性较低的氰基乙酸的活化催化剂,同时也作为大规模反应中对不均匀生成的大量二氧化碳气体的风险降低介质.该反应已扩展至多克规模,以合成商业上重要的α-氰基丙烯酸.
Doi:10.1039/b818540A