CAS: 112665-43-7; 7-Phenyl-7-(2,4,5-Trimethyl-3,6-Dioxocyclohexa-1,4-Dien-1-yl)Heptanoic Acid

上下游产品

CAS号700-13-0 三甲基氢醌 | CAS号109-63-7 三氟化硼乙醚 | CAS号103187-18-4 Z-羟基-苯庚酸 | CAS号148989-73-5 7-(2,5-二羟基-3,4,... | CAS号14794-32-2 6-(氯甲酰基)己酸乙酯 | CAS号33018-91-6 庚二酸氢乙酯 | CAS号112665-41-5 7-氧代-7-苯基庚酸乙酯

2-Phenylcycloheptanol置于二氢吡啶,间氯过氧苯甲酸,Pyridinium Chlorochromate体系中,用 二氯甲烷 用作溶剂,化学反应 46.5H,反应生成塞曲司特
参考文献:内酯与醌的催化氧化还原链开环合成含醌的羧酸
标题:内酯与醌的催化氧化还原链开环合成含醌的羧酸
摘要:五至八元内酯与醌的催化开环是通过氧化还原链机理实现的.在简单的三氟甲磺酸金属路易斯酸催化剂和链引发剂的低负载下,许多醌的c-h键被含羧酸的侧链有效地官能化.该方法还具有100%的原子经济性和广泛的底物范围.开发了一种抗哮喘药seratrodast的新途径.机理研究表明,氧化还原链反应可能发生碳正离子中间体.
Doi:10.1021/acs.Orglett.9B01672

专利信息

专利号:US-2003050305-A1
优先权日:2000-05-22
标题:Thromboxane inhibitors, compositions and methods of use
发明人：TEJADA INIGO SAENZ DE
摘要:The present invention describes methods for treating or preventing sexual dysfunctions in males and females, and for enhancing sexual responses in males and females by administering a therapeutically effective amount of at least one thromboxane inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The male or female may preferably be diabetic. The present invention also provides novel compositions comprising at least one thromboxane inhibitor, and, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and, optionally, at least one therapeutic agent, such as, vasoactive agents, nonsteroidal antiinflanmmatory compounds (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, anticoagulants, angiotensin converting enzymes (ACE) inhibitors, angiotensin II receptor antagonists, renin inhibitors, and mixtures thereof. The present invention also provides methods for treating or preventing ischemic heart disorders, myocardial infarction, angina pectoris, stroke, migraine, cerebral hemorrhage, cardiac fatalities, transient ischaemic attacks, complications following organ transplants, coronary artery bypasses, angioplasty, endarterectomy, atherosclerosis, pulmonary embolism, bronchial asthma, bronchitis, pneumonia, circulatory shock of various organs, nephritis, graft rejection, cancerous metastases, pregnancy-induced hypertension, preeclampsia, eclampsia, thrombotic and thromboembolic disorders, intrauterine growth, gastrointestinal disorders, renal diseases and disorders, disorders resulting from elevated uric acid levels and dysmenorrhea, and for inhibiting platelet aggregation or platelet adhesion or relaxing smooth muscles.

专利号:JP-2004500344-A
优先权日:1999-10-29
标 题 :Synthesis of endogenous nitric oxide under low oxygen partial pressure

专利号:US-8076315-B2
优先权日:2005-10-14
标题:Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists
发明人：CARLEY DAVID W; RADULOVACKI MIODRAG
权利人:CARLEY DAVID W; RADULOVACKI MIODRAG; UNIV ILLINOIS
摘要:This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ifetroban, diphloretin, phosphate, polyphloretin phosphate, seratrodast, SC19220). The prostanoid receptor antagonist or combination of prostanoid receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoids receptor agonists, one or more serotonin reuptake inhibitors, one or more noradrenalin reuptake inhibitors, a combination of reuptake inhibitors, an inhibitor of prostanoid synthesis, or any combination of the foregoing.

专利号:EP-1242068-A1
优先权日:1999-10-29
标 题:Endogenous nitric oxide synthesis under conditions of low oxygen tension

专利号:AU-1342901-A
优先权日:1999-10-29
标 题 :Endogenous nitric oxide synthesis under conditions of low oxygen tension

专利号:WO-0132167-A1
优先权日:1999-10-26
标题:Endogenous nitric oxide synthesis under conditions of low oxygen tension