CAS: 98048-97-6; Fosinopril

上下游产品

19H29O6PC19H29O6P trans-4-cyclohexyl-L-proline hydr°Chloride (2S,4S)-1-Benzoyl-4-phenyl-pyrrolidine-2-carboxylic acid trans-4-phenyl-L-proline

反-4-苯基-L-脯氨酸置于吡啶,盐酸,5% Rhodium-On-Charcoal,氢气,三甲基乙酰氯,三乙胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,-15.0~30.0 °C,2.0 Mpa 条件下,反应 8.0H,反应生成 福辛普利
参考文献:一种降压药福辛普利钠及其关键中间体的制 备方法
标题:一种降压药福辛普利钠及其关键中间体的制 备方法
摘要:本发明涉及适用于工业化生产的一种降压药福辛普利钠及其关键中间体反式‑4‑苯基‑l‑脯氨酸的制备方法,其中关键中间体反式‑4‑苯基‑l‑脯氨酸的合成手性选择性高,方法简便易操作.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-6717007-B1
优先权日:1999-09-16
标 题:Regiospecific synthesis of phosphonous acids
发明人：DUBEY SUSHIL KUMAR; RAJGOPAL VENKAT; SINGH ANIL VIR; LAHIRI SASWATA; WANI MUKESH JAGANNATH
权利人:LUPIN LTD
摘要:An improved regiospecific synthesis of organic phosphonous acids, comprising of hydrophosphorylation of an olefin with hydrophosphorous acid in the presence of an inorganic persulfate, which acts as a source of free radicals at a pH ranging from 4.5 to 7.0, in which the orientation of addition is anti-Markonikoff. The process enables production of organic phosphonous acids at lower temperature and atmospheric pressure under milder pH conditions for better regioselectivity in hydrophosphorylation and obtain the phosphonous acid with good yield and purity following simple isolation procedure. Phosphonous acids obtained by the process are commercially valuable as effective detergents and wetting agents, lubricants and lubricant additives, plasticizers for plastics and resins, corrosion inhibitors, chemicals including insecticides and pesticides, cobalt extractants and as key intermediates for preparation of commercially important angiotensin converting enzyme (ACE) inhibitors.

专利号:US-7582758-B2
优先权日:2004-06-08
标 题:Lewis acid mediated synthesis of cyclic esters
发明人：MARTIN KEVIN V
权利人:METABASIS THERAPEUTICS INC
摘要:Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.

专利号:US-8431712-B2
优先权日:2004-02-09
标 题 :Methods for the synthesis of pyridoxamine
发明人：KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT
权利人:KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT; NEPHROGENEX INC
摘要:The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): n nand salts thereof.n nThe invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.

专利号:US-5362899-A
优先权日:1993-09-09
标题:Chiral synthesis of alpha-aminophosponic acids
发明人：CAMPBELL DAVID A
权利人:AFFYMAX TECH NV
摘要:A stereospecific method of preparing alpha-aminophosphonic acids and derivatives thereof is provided. A protected amino acid is converted to a acyl aroyl or diacyl peroxide which spontaneously rearranges to form an alpha-amino ester. This rearrangement occurs stereospecifically with retention of configuration. The ester is subsequently converted to an appropriate leaving group and displaced with a phosphite yielding a chiral alpha-aminophosphonic acid or derivative. n Alpha-aminophosphonic acids are useful for the synthesis of peptide analogs that possess a phosphonate linkage in the place of an amide linkage. This substitution can impart protease resistance in therapeutic peptides thereby increasing the serum half-life.