CAS: 94608-23-8; Cis-Trismethoxy Resveratrol

化学文摘社编号为94608-23-8,是用于监管和研究目的的独特识别数据.许多二苯衍生物,化合物的稳定性,溶解性和再活性都受到光温度等环境因素的影响.

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CAS号400608-31-3 1,3-dimethoxy-5... | CAS号441351-32-2 (Z)-紫檀茋 | CAS号74-88-4 碘甲烷 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号2746-25-0 4-甲氧基溴苄 | CAS号7311-34-4 3.5-二甲氧基苯甲醛 | CAS号1530-38-7 (4-甲氧基苄基)(三苯基)溴化膦 | CAS号877-88-3 3,5-二甲氧基苄溴 | CAS号24131-30-4 (3,5-DIMETHOXYB... | CAS号501-36-0 白藜芦醇

合成工艺路线路线简述

  • 22255-22-7 = 94608-23-8
    反应条件:1.1 Solvents: Ethanol; 1 H
    标题:Method For The Synthesis Of (Z)-3,5,4'-Trimethoxystilbene,A Trimethyl Derivative Of Resveratrol,The Resulting Compound,And Uses Of Said Compound,In Particular As A Medicine,And Particularly As An Anticancer Drug
    参考文献:World Intellectual Property Organization]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: 1,10-Phenanthroline,Quinoline,Copper; 50 Min,Heated1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 6,Cooled
    标题:Method For Preparing Diphenylethylene From 2,3-Diphenyl Acrylic Acid
    参考文献:China]

    400608-31-3 = 94608-23-8
    反应条件:1.1 Reagents: Chlorotrimethylsilane,Hydrogen,Magnesium Catalysts: (Oc-6-31)-Aqua[1-[2,6-Bis(1-Methylethyl)Phenyl]-3-[1-[[2,6-Bis(1-Methylethyl)Phe... Solvents: Tetrahydrofuran; 24 H,90 - 100 °C
    标题:Chromium-Catalyzed Stereodivergent E- And Z-Selective Alkyne Hydrogenation Controlled By Cyclic (Alkyl)(Amino)Carbene Ligands
    作者:Ling,Liang; Hu,Chenyang; Long,Linhong; Zhang,Xue; Zhao,Lixing; Et Al
    参考文献:Nature Communications 日期:2023 卷标:14(1)]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: Quinoline,Sodium Hydroxide Catalysts: Copper; 0.25 H,200 °C
    标题:Synthesis Of Resveratrol
    作者:Hou,Bing-Bo; Feng,Jiang-Jiang; Yang,Sheng-Wei; Ao,Gui-Zhen
    参考文献:Huaxue Shiji 日期:2011 卷标:33(12) 页码:1141-1143]

    909717-00-6 = 94608-23-8
    反应条件:1.1 Reagents: Quinoline Catalysts: Copper; 3 H,220 °C
    标题:Efficient Synthesis Of Natural Polyphenolic Stilbenes: Resveratrol,Piceatannol And Oxyresveratrol
    作者:Sun,Hong-Yi; Xiao,Chun-Fen; Cai,Yu-Chen; Chen,Yu; Wei,Wen; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:2010 卷标:58(11) 页码:1492-1496]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: Quinoline,Copper Catalysts: 1,10-Phenanthroline; 6 Min1.2 Reagents: Hydrochloric Acid Solvents: Water; Cooled
    标题:Microwave-Assisted And Ligand-Accelerated Decarboxylation Of 2,3-Diaryl Acrylic Acids
    作者:Liu,Xianke; Wu,Wei; Lv,Zeliang; Zou,Yong
    参考文献:Huaxue Tongbao 日期:2012 卷标:75(6) 页码:526-531]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: Quinoline,Copper; 3 H,200 °C
    标题:Hydroxyl Substitutional Effect On Selective Synthesis Of Cis,Trans Stilbenes And 3-Arylcoumarins Through Perkin Condensation
    作者:Xiao,Chun-Fen; Zou,Yong; Du,Jian-Li; Sun,Hong-Yi; Liu,Xian-Ke
    参考文献:Synthetic Communications 日期:2012 卷标:42(9) 页码:1243-1258]

    1229971-87-2 + 696-62-8 = 94608-23-8
    反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Diethyl Ether; 0 °C; 0 °C -> Rt; 16 H,Rt1.2 Reagents: Tetrabutylammonium Fluoride Catalysts: Bis(Dibenzylideneacetone)Palladium Solvents: Tetrahydrofuran
    标题:Diversity-Oriented Synthesis Of Disubstituted Alkenes Using Masked Silanols
    作者:Sore,Hannah F.; Blackwell,David T.; Macdonald,Simon J. F.; Spring,David R.
    参考文献:Organic Letters 日期:2010 卷标:12(12) 页码:2806-2809]

    22255-22-7 = 94608-23-8
    反应条件:1.1 Solvents: Ethanol; 1 H,Rt
    标题:Anti-Mitotic Properties Of Resveratrol Analog (Z)-3,5,4'-Trimethoxystilbene
    作者:Chabert,Philippe; Fougerousse,Andre; Brouillard,Raymond
    参考文献:Biofactors 日期:2006 卷标:27(1-4) 页码:37-46]

    1530-38-7 + 7311-34-4 = 94608-23-8
    反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Isopropanol; 60 °C
    标题:E-Selective Isomerization Of Stilbenes And Stilbenoids Through Reversible Hydroboration
    作者:Gray,Erin E.; Rabenold,Lake E.; Goess,Brian C.
    参考文献:Tetrahedron Letters 日期:2011 卷标:52(46) 页码:6177-6179]

    441351-32-2 = 94608-23-8
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 5 H,Reflux
    标题:Synthesis Of Radiolabeled Stilbene Derivatives As New Potential Pet Probes For Aryl Hydrocarbon Receptor In Cancers
    作者:Gao,Mingzhang; Wang,Min; Miller,Kathy D.; Sledge,George W.; Hutchins,Gary D.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2006 卷标:16(22) 页码:5767-5772]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Catalysts: Chromium Copper Oxide (Cr2Cuo4) Solvents: Pyridine; Rt -> 240 °C; 1 - 2 H,230 - 240 °C; 240 °C -> Rt
    标题:Improved Method For Synthesizing Resveratrol
    参考文献:China]

    400608-31-3 = 94608-23-8
    反应条件:1.1 Reagents: Lithium Tert-Butoxide,Bis(Neopentyl Glycolato)Diboron Catalysts: (2-Thiophenecarboxylato-Ko2,Ks1)Copper,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Dimethylformamide,Water; 24 H,60 °C
    标题:Copper-Catalysed,Diboron-Mediated Cis-Dideuterated Semihydrogenation Of Alkynes With Heavy Water
    作者:Han,Xiaowei; Hu,Jiefeng; Chen,Cheng; Yuan,Yu; Shi,Zhuangzhi
    参考文献:Chemical Communications (Cambridge 日期:2019 卷标:55(48) 页码:6922-6925]

    400608-31-3 = 94608-23-8
    反应条件:1.1 Reagents: Deuterium,[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Hydroxy... Catalysts: 1,1-Bis(Diphenylphosphino)Ferrocene,Nickel Iodide (Nii2) Solvents: Tetrahydrofuran; 100 Bar,60 °C
    标题:A Simple Nickel Catalyst Enables Broad E-Selective Alkyne Semihydrogenation
    作者:Thiel,Niklas O.; Kaewmee,Benyapa; Ngoc,Trung Tran; Teichert,Johannes F.
    参考文献:Chemrxiv 日期:2019 卷标:1 页码:1-7]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: Quinoline,Potassium Hydroxide,Copper Bromide (Cubr); 0.5 H,190 °C
    标题:Method For Preparation Of (E)-Resveratrol
    参考文献:China]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: Tributylamine Catalysts: Copper Oxide (Cu2O) Solvents: N-Methyl-2-Pyrrolidone; 90 Min,200 °C
    标题:Stereospecific Synthesis Of Cis-Stilbenes From Benzaldehydes And Phenylacetic Acids Via Sequential Perkin Condensation And Decarboxylation
    作者:Thompson,Clayton M.; Orellana,Matthew D.; Lloyd,Shannon E.; Wu,Weiming
    参考文献:Tetrahedron Letters 日期:2016 卷标:57(43) 页码:4866-4868]

    20469-65-2 = 94608-23-8
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Palladium Diacetate,2-Dicyclohexylphosphino-2′,6′-Dimethoxybiphenyl Solvents: Tetrahydrofuran; 6 H,23 °C
    标题:(Z)-(2-Bromovinyl)-Mida Boronate: A Readily Accessible And Highly Versatile Building Block For Small Molecule Synthesis
    作者:Woerly,Eric M.; Struble,Justin R.; Palyam,Nagarjuna; O'Hara,Sean P.; Burke,Martin D.
    参考文献:Tetrahedron 日期:2011 卷标:67(24) 页码:4333-4343]

    959961-16-1 = 94608-23-8
    反应条件:1.1 Reagents: Copper Solvents: Quinoline; 4 H,220 °C
    标题:An Efficient Synthesis Of Resveratrol And A Hydroxyl Derivative Via The Perkin Reaction: Cis To Trans Isomerization In A Demethylation Process
    作者:Li,Guoxing; Zou,Yong; Zhang,Xuejing
    参考文献:Journal Of Chemical Research 日期:2007 卷标:(11) 页码:657-659]

    1530-38-7 + 7311-34-4 = 94608-23-8
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 30 Min,-78 °C; 1 H,Rt; Rt -> -78 °C1.2 Solvents: Tetrahydrofuran; 1 H,-78 °C; 18 H,Rt
    标题:2-Amino And 2'-Aminocombretastatin Derivatives As Potent Antimitotic Agents
    作者:Chang,Jang-Yang; Yang,Ming-Fang; Chang,Chi-Yen; Chen,Chi-Ming; Kuo,Ching-Chuan; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(21) 页码:6412-6415]

    400608-31-3 = 94608-23-8
    反应条件:1.1 Reagents: Hydrogen Solvents: Ethanol; 3.3 Min,2 Bar,60 °C
    标题:Preparation Of Substituted Electron Rich Diphenylacetylenes And Stilbene Derivatives
    参考文献:World Intellectual Property Organization
📜3,4',5-三甲氧基-反-二苯代乙烯置于tris(Bipyridine)Ruthenium(II) Dichloride Hexahydrate体系中,用 氘代二甲亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.5H,反应生成 顺式白藜芦醇三甲醚
参考文献:通过光催化异构化对治疗剂进行光化学控制
标题:通过光催化异构化对治疗剂进行光化学控制
摘要:使用 Ru(Bpy) 3 Cl 2光催化剂,可以实现一系列基于烯烃核心的药物的快速反式到顺式异构化.其中包括康布他汀 A-4 (Ca-4),一种肿瘤学临床候选药物和白藜芦醇衍生物,允许它们在纤维素活化中具有选择性.这为未经修饰的药剂的快速原位激活提供了一个新平台.
DOI:10.1002/anie.202203390

海关参考信息

专利信息


专利号:WO-03031381-A3
优先权日:2001-10-12
标题:Synthesis of (z)-3,5,4'-trimethoxystilbene, and use thereof
发明人：RAUL FRANCIS; SCHNEIDER YANN; BROUILLARD RAYMOND; FOUGEROUSSE ANDRE; CHABERT PHILIPPE; GONZALEZ EMMANUEL
权利人:UNIV PASTEUR; INST NAT SANTE RECH MED; CENTRE NAT RECH SCIENT; RAUL FRANCIS; SCHNEIDER YANN; BROUILLARD RAYMOND; FOUGEROUSSE ANDRE; CHABERT PHILIPPE; GONZALEZ EMMANUEL
摘要:The invention concerns the field of organic chemistry and more particularly that related to the synthesis of novel molecules capable of exhibiting biological properties, in particular therapeutic and more particularly properties for preventing or treating certain diseases such as in particular cancer-type diseases. The invention concerns a novel method for chemical synthesis of (Z)-3,5,4'-trimethoxystilbene (compound R3), the compound obtainable by said method, the use of said compound as medicine in particular as synthetic anticancer drug at low production cost, the corresponding medicine and various uses of said compound (R3).

专利号:US-12180228-B2
优先权日:2019-06-05
标题:Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
发明人：MOVASSAGHI MOHAMMAD; OLSSON CHASE ROBERT; SCOTT TONY Z; CHEAH JAIME; PAYETTE JOSHUA NATHANIEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

专利号:US-2021329919-A9
优先权日:2019-07-01
标 题:Synthesis and anti-cancer activity of communesin alkaloids
发明人：MOVASSAGHI MOHAMMAD; POMPEO MATTHEW M; CHEAH JAIME
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are compounds of Formula (I):and salts, tautomers, and stereoisomers thereof. Methods of making the compounds, salts, tautomers, and stereoisomers are also described. Further described herein are composition, kits, methods, and uses involving the compounds, salts, tautomers, and stereoisomers. The methods include methods of treating and preventing diseases (e.g., cancers) in subjects (e.g., humans).

专利号:WO-03031381-A2
优先权日:2001-10-12
标 题:Synthesis of (z)-3,5,4'-trimethoxystilbene, and use thereof

专利号:WO-2009105123-A1
优先权日:2008-02-22
标 题:Compounds, compositions and methods for treating or preventing diseases
发明人：DANISHEFSKY SAMUEL J; CHOU TING-CHAO; LEI XIAOGUANG
权利人:UNIV COLUMBIA; DANISHEFSKY SAMUEL J; CHOU TING-CHAO; LEI XIAOGUANG
摘要:The present invention provides compounds of Formula (I), compositions comprising an effective amount of a Compound of Formula (I), optionally with a tubulin-binding drug, methods of their use for treating or preventing cancer or a neurotrophic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, and methods for making Compounds of the invention.

专利号:US-8859615-B2
优先权日:2008-08-27
标题 :Compounds, compositions and methods for reducing toxicity and treating or preventing diseases
发明人：DANISHEFSKY SAMUEL J; CHOU TING-CHAO; LEI XIAOGUANG; YUN HEEDONG; NG FAY; HARTUNG JOHN; SAMES DALIBOR
权利人:DANISHEFSKY SAMUEL J; CHOU TING-CHAO; LEI XIAOGUANG; YUN HEEDONG; NG FAY; HARTUNG JOHN; SAMES DALIBOR
摘要:The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).

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摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 45, 210.
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