CAS: 924663-37-6; 2-(((1H-Benzo[d]Imidazol-2-yl)Sulfonyl)Methyl)-4-(3-Methoxypropoxy)-3-Methylpyridine 1-Oxide

该化合物是一种属于质子泵抑制剂类的化学化合物,是Rebepratole的衍生物,主要用于治疗胃腔复发性病(GERD)和其他与过度生产胃酸相关的条件; 全氟辛烷磺酸的改变会增强它的药理特性,有可能提高其功效和稳定性; 这种复合物通常具有极地溶剂的高溶性等特征,有利于其生物利用率; 此外,它可能拥有一种特定的分子结构,有助于其行动机制,抑制气态子类细胞中的质子泵,从而减少酸性分泌;再生子氧化盐磺磺的安全和副作用通常与其他PPI的特性相一致,包括胃肠扰动和与其他药物的潜在相互作用; 与任何制药化合物一样,其使用应当以临床证据和监管批准为指导.

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物理性质

MSDS等安全信息

上下游产品

2-[[(4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole rabeprazole sulfide 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide 2-[(4-chloro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazoleLY 307640 sulfone

合成工艺路线路线简述

  • 924663-40-1 = 924663-37-6
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Sodium Tungsten Oxide (Na2Wo4) Solvents: Methanol,Dimethylformamide,Water; 25 °C; 2 H,25 °C; 25 °C -> 40 °C
    标题:Synthesis And Structural Identification Of The Related Substances Of Rabeprazole Sodium
    作者:Tong,Qiao-Lin; Wang,Qing-He; Ma,Wen-Xi; Zhang,Meng; Cheng,Mao-Sheng
    参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2016 卷标:26(2) 页码:139-141]

    924663-40-1 = 924663-37-6 + 924663-38-7
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Dichloromethane; 145 Min,0 °C; 15 Min,0 °C
    标题:Efficient Synthesis Of N-Oxide Derivatives: Substituted 2-(2-(Pyridyl-N-Oxide)Methylsulphinyl)Benzimidazoles
    作者:Ray,Purna C.; Mittapelli,Vasantha; Rohatgi,Amit; Tyagi,Om Dutt
    参考文献:Synthetic Communications 日期:2007 卷标:37(17) 页码:2861-2868]

    117976-89-3 = 924663-37-6
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Methanol,Chloroform,Water; 45 Min,-10 - -5 °C1.2 Reagents: Sodium Hydroxide Solvents: Water1.3 Reagents: Acetic Acid; Ph 7 - 7.51.4 Reagents: Sodium Hydroxide Solvents: Water; Basified1.5 Reagents: Acetic Acid Solvents: Acetone; Rt; Rt -> 5 °C; Ph 8 - 8.5,5 °C
    标题:Synthesis Of Metabolites And Related Substances Of Rabeprazole,An Anti-Ulcerative Drug
    作者:Reddy,Ganta Madhusudhan; Mukkanti,Kaga; Bhaskar,Boluggodu Vijaya; Reddy,Padi Pratap
    参考文献:Synthetic Communications 日期:2009 卷标:39(2) 页码:278-290]

    117977-21-6 = 924663-37-6
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Acetone; 24 H,Rt
    标题:Process For Preparation Of Rabeprazole Correlate D
    参考文献:China]

    924663-40-1 = 924663-37-6
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Dichloromethane,Water; Cooled1.2 Reagents: Peracetic Acid Solvents: Water; 30 Min,Cooled; 24 H,Rt; 8 H,Rt; 20 H,Rt
    标题:Synthetic Studies Connected With The Preparation Of H+/k+-Atpase Inhibitors Rabeprazole And Lansoprazole
    作者:Radl,Stanislav; Klecan,Ondrej; Havlicek,Jaroslav
    参考文献:Journal Of Heterocyclic Chemistry 日期:2006 卷标:43(6) 页码:1447-1453
📜雷贝拉唑置于间氯过氧苯甲酸体系中,用 甲醇,氯仿 作为反应溶剂,以80%的收率获得产物雷贝拉唑砜 N-氧化物
参考文献:抗溃疡药雷贝拉唑代谢物及相关物质的合成
标题:抗溃疡药雷贝拉唑代谢物及相关物质的合成
摘要:摘要 雷贝拉唑钠 (Aciphex®) 是一种胃质子泵抑制剂,用于预防和治疗胃酸相关疾病.在雷贝拉唑钠原料药的合成过程中,我们观测到代谢产物雷贝拉唑硫化物和雷贝拉唑砜以及相关物质雷贝拉唑-N-氧化物,雷贝拉唑砜-N-氧化物,N-芳烷基雷贝拉唑,氯雷贝拉唑和甲氧基雷贝拉唑作为杂质存在药物物质.目前的工作描述了这些化合物的合成和表征.
DOI:10.1080/00397910802372541

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主要参考文献

参考标题:Synthetic Studies Connected With The Preparation Of H+/k+-Atpase Inhibitors Rabeprazole And Lansoprazole
作者:Stanislav Rédl,Ondřej Klecén,Jaroslav Havlíček |发布日期:2006.11
摘要:Synthesis Of Lansoprazole And Rabeprazole Using Common Intermediates Is Devised. The Common Intermediates, 2-[(4-Nitro-3-Methylpyridin-2-Yl)Methanesulfanyl]-1H-Benzoimidazole And 2-[(4-Chloro-3-Methyl-Pyridin-2-Yl)Methanesulfanyl]-1H-Benzoimidazole, Were Prepared In Several Ways.

合成参考文献


参考文献:10.1016/j.jpba.2006.10.017
摘要:Reddy GM, Bhaskar BV, Reddy PP, Sudhakar P, Babu JM, Vyas K, Reddy PR, Mukkanti K. Identification and characterization of potential impurities of rabeprazole sodium. Journal of Pharmaceutical and Biomedical Analysis. 2007 Mar;43(4):1262–9. doi: 10.1016/j.jpba.2006.10.017.
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