2935-35-5 + 99-33-2 = 90761-62-9 反应条件:1.1 Solvents: Tetrahydrofuran; 1 W,Rt 标题:Chiral Permselectivity In Nanoporous Opal Films Surface-Modified With Chiral Selector Moieties 作者:Cichelli,Julie; Zharov,Ilya 参考文献:Journal Of Materials Chemistry 日期:2007 卷标:17(19) 页码:1870-1875]
2935-35-5 + 99-33-2 = 90761-62-9 反应条件:1.1 Solvents: Tetrahydrofuran 标题:A-(Modified B6)-B-[ω-Amino(Ethylamino)]-β-Cyclodextrin As An Artificial B6 Enzyme For Chiral Aminotransfer Reaction 作者:Tabushi,Iwao; Kuroda,Yasuhisa; Yamada,Masahiko; Higashimura,Hideyuki; Breslow,Ronald 参考文献:Journal Of The American Chemical Society 日期:1985 卷标:107(19) 页码:5545-6
📜苯甲酰甲酸置于a-(Modified B6)-B-<ω-Amino(Ethylamino)>-β-Cyclodextrin体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 5.0H,反应生成 N-(3,5-二硝基苯甲酰)-L-α-苯基甘氨酸 参考文献:A-(Modified B6)-B-[.Omega.-Amino(Ethylamino)]-.Beta.-Cyclodextrin As An Artificial B6 Enzyme For Chiral Aminotransfer Reaction 标题:A-(Modified B6)-B-[.Omega.-Amino(Ethylamino)]-.Beta.-Cyclodextrin As An Artificial B6 Enzyme For Chiral Aminotransfer Reaction 摘要: DOI:10.1021/ja00305A048
专利号:US-8981121-B2 优先权日:2010-06-25 标 题 :Process for the preparation of nitrogen substituted aminotetralins derivatives 发明人:ATES CELAL; SCHULE ARNAUD; PALACIO MAGALI; DEUTSCH PAUL; VASSELIN DAVID; CARLY NICOLAS; PHADTARE GANESH; YERANDE SWAPNIL; DELATINNE JEAN-PIERRE; ESCUDERO HERNANDEZ MARIA LUISA; PINILLA VERONIQUE 权利人:ATES CELAL; SCHULE ARNAUD; PALACIO MAGALI; DEUTSCH PAUL; VASSELIN DAVID; CARLY NICOLAS; PHADTARE GANESH; YERANDE SWAPNIL; DELATINNE JEAN-PIERRE; ESCUDERO HERNANDEZ MARIA LUISA; PINILLA VERONIQUE; UCB PHARMA GMBH 摘要:The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R 1 , R 2 and R 3 are as defined for compound of formula (I).
专利号:US-7420070-B2 优先权日:2000-12-28 标 题:Process for preparing optically active 2,3-dihydrobenzofuran compounds 发明人:AOKI ISAO; ADACHI MARI; TAWADA HIROYUKI; YAMASHITA MAKOTO; SERA MISAYO 权利人:TAKODA PHARMACEUTICAL COMPANY 摘要:A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: n n[wherein R 1 and R 2 are each hydrogen or an optionally substituted hydrocarbon group; R 3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:EP-0965591-A1 优先权日:1991-06-21 标 题 :(s)-3-methyl-1-(2-piperidino-phenyl)-1-butylamine, its salts, synthesis and use in the long term therapy of diabetes mellitus
参考文献:10.1021/ja058004x 摘要:Chen Z, Yang Y, Werner S, Wipf P, Weber SG. A screening method for chiral selectors that does not require covalent attachment. J Am Chem Soc. 2006 Feb 22;128(7):2208–9.