2,5-二氯硝基苯置于nh2体系中,化学反应生成 4-氯-2-硝基苯胺 参考文献:Pyrrolylquinoxalinediones: A New Class Of Ampa Receptor Antagonists 标题:Pyrrolylquinoxalinediones: A New Class Of Ampa Receptor Antagonists 摘要:Pyrrolylquinoxalinediones Were Synthesized And Their Affinities For The Ampa Receptor Were Determined. Most Compounds Showed Moderate To Good Affinities. The Acetic Acid Derivative 8B Exhibited A K-I Value Of 70 Nm And Was Equipotent To Nbqx 1. Structure Activity Relationships Are Discussed. Selected Compounds Were Tested For Their Potency To Inhibit Ampa Induced Lethal Convulsions In Mice. In This In Vivo Model The Compounds Showed Improved Potency Compared With Nbqx. Copyright (C) 1996 Elsevier Science Ltd DOI:10.1016/s0960-894X(96)00534-3
专利号:US-7825257-B1 优先权日:2007-10-23 标题 :Synthesis of benzotriazole monomer 发明人:DEO KESHAV; SHAH CHANDRAKANT CHUNILAL; PATEL KALPESH; PATEL NILPESH; PAREKH VIRAL; PATEL RONAK; SONI JIGNESH; SHAH HIRAL; SEELYE DAVID E; NANDU MAHENDRA P 权利人:BAUSCH & LOMB 摘要:The synthesis of benzotriazole monomers and the use of the benzotriazole monomers and one or more other monomers to prepare ultraviolet (UV) light absorbing polymer compositions. The synthetic methods described in this application provide a significant improvement over the previous methods used to prepare benzotriazole monomers.
专利号:WO-2019239202-A1 优先权日:2018-06-11 标题:Novel & improved synthesis of antipsychotic drug 发明人:DUBEY DR RAJEEV KUMAR; SIRUGU BATTULA VENKAT RAO; POTLURI RAMESH BABU; POTLURI VAMSI KRISHNA; GARIKIPATI SHIVA KRISHNA 权利人:SMS PHARMACEUTICALS LTD 摘要:The present invention relates to novel as well as improved process for the preparation of Clozapine of Formula I which involves anti-narcotic and highly cost effective raw materials.
专利号:US-11993800-B2 优先权日:2017-05-26 标题:Use of terminal transferase enzyme in nucleic acid synthesis 发明人:CHEN MICHAEL; HUANG JIAHAO; MCINROY GORDON 权利人:NUCLERA LTD 摘要:The invention relates to the use of a modified terminal transferase enzyme in a method of adding one or more nucleotides to the 3′ end of a nucleic acid. The invention also relates to methods of nucleic acid synthesis and sequencing comprising the use of said modified terminal transferase enzyme, to kits comprising said modified terminal transferase enzyme and to the use of said kits in methods of nucleic acid synthesis and sequencing.
专利号:WO-2025107145-A1 优先权日:2023-11-21 标题:Continuous synthesis method for disperse yellow dye 发明人:TAO GUOLAI; TAO ANDI; DING YONGCAI; YANG JIE; MOU ZHONGYUE 权利人:LEPING SAFELY PHARMACEUTICAL CO LTD 摘要:The present invention relates to the technical field of fine organic chemicals, and provides a continuous synthesis method for a disperse yellow dye. Continuous tubular reaction technology is used. A continuous tubular reactor provided by the present invention has a small volume, a large specific surface area, and a large heat transfer area per unit volume. The continuous tubular reactor can promptly transfer reaction heat by means of heat exchange and can ensure safety while accelerating the feeding speed. The continuous tubular reaction provided by the present invention precisely controls a raw material ratio, so that a feeding ratio of main raw materials is close to a theoretical value. In addition, by means of introducing an automatic control system, the chemical reaction can be carried out at a raw material ratio that strictly follows an optimal set value. The mass transfer and heat transfer effect of the continuous reactor is relatively good. Following the improvement to the mass transfer and heat transfer effect, the temperature control is more precise, and the generation of by-products is reduced.
专利号:US-4719053-A 优先权日:1980-08-01 标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates 发明人:SCHLAEFER LUDWIG; HAEHNLE REINHARD 权利人:HOECHST AG 摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.
专利号:US-4740604-A 优先权日:1986-05-26 标题:Benzanthrone lactones 发明人:WEIS CLAUS D; SUTTER PETER 权利人:CIBA GEIGY CORP 摘要:There are disclosed benzanthrone lactones of formula ##STR1## wherein R 1 , R 2 and R 3 are as defined in claim 1. The benzanthrone lactones of formula (1) are important intermediates for the synthesis of novel dyes which are obtained by coupling suitable diazo components to said compounds of formula (1).
摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 428. 摘要:J. G. Dawber and P. A. H. Wyatt. J. Chem. Soc. 1960, 3589. 摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990) 摘要:Weast, R.C. and M.J. Astle. CRC Handbook of Data on Organic Compounds. Volumes I and II. Boca Raton, FL: CRC Press Inc. 1985., p. V1 72 摘要:IMDG; International Maritime Dangerous Goods Code; International Maritime Organization p.6099 (1988)