CAS: 611-70-1; Isobutyrophenone

上下游产品

CAS号79-30-1 异丁酰氯 | CAS号71-43-2 苯 | CAS号611-69-8 2-甲基-1-苯基-1-丙醇 | CAS号78-82-0 异丁腈 | CAS号98-80-6 苯硼酸 | CAS号538-93-2 异丁基苯 | CAS号10409-54-8 2-溴异丁酰苯 | CAS号75-30-9 2-碘代丙烷 | CAS号29329-26-8 2,2-dimethyl-2-... | CAS号10326-99-5 2-methyl-1-(4-n... | CAS号49660-91-5 2-methyl-2'-nit... | CAS号34857-28-8 (S)-2-甲基-1-苯基丙-1-醇 | CAS号14898-86-3 R-(+)-2-甲基-1-苯基-1-丙醇 | CAS号67-64-1 丙酮 | CAS号59214-60-7 2,5-dimethyl-3,... | CAS号4481-30-5 (1,2-二甲基丙基)苯 | CAS号532-32-1 苯甲酸钠 | CAS号93-89-0 苯甲酸乙酯

Methyl (2-Methyl-1-Oxo-1-Phenylpropan-2-yl) Oxalate置于2-(2-吡啶)-苯并咪唑,二苯基硅烷,Magnesium Chloride,Nickel Dichloride,锌体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,以50%的收率获得产物异丁酰苯
参考文献:锌介导的叔烷基草酸酯的加氢脱氧
标题:锌介导的叔烷基草酸酯的加氢脱氧
摘要:本文中,我们描述了在ni催化条件下通过zn /硅烷对易获得的叔烷基草酸酯进行加氢脱氧的一般,温和和可扩展的方法.还原方法适用于衍生自带有不同官能团的叔醇的一系列结构基序,包括在通往雌酮的途中合成关键中间体.
DOI:10.1055/a-1328-0352

专利信息

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

专利号:US-7202370-B2
优先权日:2003-10-27
标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
发明人：NAIDU RAGINA
权利人:CONOR MEDSYSTEMS INC
摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.

专利号:US-2024024497-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.

专利号:US-2005192445-A1
优先权日:2004-03-01
标题:Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:PHYTOGEN LIFE SCIENCES INC
摘要:A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannne and baccatin III intermediates, and the conversion of such intermediates and analogues to paclitaxel and docetaxel.