CAS: 56502-01-3; (S)-2-(1-Boc-2-Pyrrolidinyl)Acetic Acid

相似化合物

194154-91-1 101555-60-6 53912-85-9

上下游产品

CAS号88790-37-8 METHYL (2S)-PYR... | CAS号88790-38-9 (2S)-2-(2-羟乙基)吡... | CAS号101130-03-4 (L)-2-二氮杂乙酰基吡咯烷... | CAS号15761-39-4 B°C-L-脯氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号56633-75-1 (S)-吡咯烷乙酸 | CAS号53912-83-7 (S)-2-(2-吡咯烷基)乙酸甲酯

Tert-Butyl (S)-2-(Diazoacetyl)Pyrrolidine-1-Carboxylate置于silver Benzoate体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 6.0H,以80%的收率获得产物boc-L-Beta-高脯氨酸
参考文献:Homologation Of α-Amino Acids To β-Amino Acids Using Boc2O
标题:Homologation Of α-Amino Acids To β-Amino Acids Using Boc2O
摘要:在利用arndt-Eistert方法将n-羟基脲保护的α-氨基酸同系化为其β-同系物的过程中,使用boc2O作为偶联剂的方法已被描述.该同系化反应能够获得非常好的产率,且不会发生消旋化.使用boc2O作为偶联剂不仅使得过程易于放大,而且在成本方面也是经济有效的.
DOI:10.1039/b204652K

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2012172350-A1
优先权日:2009-09-11
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.