📜苜蓿素-7-O-葡萄糖苷置于盐酸体系中,用 甲醇,水 作为反应溶剂,化学反应 4.0H,反应生成 苜蓿素 参考文献:异源多倍体 Spartina Anglica 中的类黄酮模式遗传--与亲本 S. Maritima 和 S. Alterniflora 的比较 标题:异源多倍体 Spartina Anglica 中的类黄酮模式遗传--与亲本 S. Maritima 和 S. Alterniflora 的比较 摘要:入侵物种 Spartina Anglica 起源于欧洲,由非洲-欧洲物种 S. Maritima(本地,父系祖先)和引入的北美互花米草(入侵,母系祖先)杂交而成.从植物组织中制备含水甲醇提取物,用于三个物种之间的化学分类比较,并确定 S. Anglica 中的酚类遗传.在 S. Anglica 和 S. Alterniflora 的地上组织中共检测到 20 种酚类化合物,但在 S. Maritima 中仅检测到 7 种酚类化合物.它们从各自的粗提物中分离出来,并根据光谱数据分析和化学证据确定了它们的结构.它们都属于黄酮类,其中 13 种被鉴定为 C-糖类黄酮,7 种被鉴定为 O-糖类黄酮.所有这些产品均为首次从s. Anglica 中检测到,其中14 种为首次从s. Alterniflora 中检测到,其中3 种为首次从s. Maritima 中检测到.通过定量 HPLC 测定三种物质中的 DOI:10.1016/j.Phytochem.2020.112312
专利号:WO-2020032913-A1 优先权日:2018-08-04 标题:Process for synthesis of oroxylin a 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA 摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalm is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A gluciironide methyl ester which on de- glycosylation results in the formation of Oroxylin A.
专利号:US-2009221568-A1 优先权日:2005-11-04 标题:Synthesis of Inhibitors of FtsZ 发明人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY 权利人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY 摘要:FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2′″-hydroxy-5″-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.
专利号:WO-2025081225-A1 优先权日:2023-10-17 标 题 :Synthesis of polyphenols 发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT 权利人:Delica Therapeutics Pty Ltd 摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.
专利号:US-5262312-A 优先权日:1990-04-25 标 题:Process for the glycosidase-catalyzed synthesis of glyco conjugates 发明人:HOLLA WOLFGANG; SCHUDOK MANFRED 权利人:HOECHST AG 摘要:It has been possible to show for a first time with the process according to the invention that the synthesis of glyco conjugates is possible by direct linkage of sugars with serine, serine derivatives and serine peptides with the aid of glucosidases.
专利号:EP-2017267-A1 优先权日:2007-07-16 标 题:Synthesis of statins 发明人:KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ 权利人:LEK PHARMACEUTICALS 摘要:The process for synthesis of statins is presented where the intermediate intermediate (4 R ,6 S )-6-(dialkoxymethyl)tetrahydro-2 H -pyran-2,4-diol which already possesses the desired stereochemistry corresponding to final statin is prepared by an aldolaze.
专利号:US-10407401-B1 优先权日:2018-08-04 标题 :Process for synthesis of Oroxylin A 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA; SAMI LABS LTD 摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.
参考文献:10.1016/j.antiviral.2011.06.014 摘要:Akuzawa K, Yamada R, Li Z, Li Y, Sadanari H, Matsubara K, Watanabe K, Koketsu M, Tuchida Y, Murayama T. Inhibitory effects of tricin derivative from Sasa albo-marginata on replication of human cytomegalovirus. Antiviral Res. 2011 Sep;91(3):296–303. doi: 10.1016/j.antiviral.2011.06.014. 摘要:Matsuta T, Sakagami H, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Kitajima M, Oizumi H, Oizumi T. Biological activity of luteolin glycosides and tricin from Sasa senanensis Rehder. In Vivo. 2011 Sep;25(5):757–62.