CAS: 4273-98-7; 2-(Phenylsulfonyl)Aniline

上下游产品

1-nitro-2-(phenylsulfonyl)benzene N-phenylbenzenesulfonamide acetic acid-(2-benzenesulfonyl-anilide) 2-Nitrosophenyl-phenylsulfon 1-bromo-2-(phenylsulfonyl)benzene acetic acid-(2-benzenesulfonyl-anilide) dibenzothiophene sulfone 2,2'-diaminodiphenyl sulfone

2-硝基二苯砜置于盐酸,Tin体系中,化学反应生成 2-氨基二苯砜
参考文献:二芳基衍生物中的邻近效应.第四部分 2,2'-二(羟基氨基)二芳基砜和2-(羟基氨基)芳基苯基砜的碱催化反应
标题:二芳基衍生物中的邻近效应.第四部分 2,2'-二(羟基氨基)二芳基砜和2-(羟基氨基)芳基苯基砜的碱催化反应
摘要:2,2'-二(羟基氨基)二芳基砜与氢氧化钠在二恶烷水溶液中于20°反应反应生成二苯并[B,F] [1,4,5]噻二氮杂5,11,11-三氧化物(x),吩嗪5-氧化物(xiv)和吩嗪5,10-二氧化物(xv).吩嗪衍生物的形成可能涉及芳基羟胺的歧化,然后是smiles重排,然后是磺基的损失.在锌的存在下,芳基羟胺被转化为吩嗪(iv)和噻二氮杂11,11-二氧化物(vii).鉴于这些结果,讨论了2,2'-二硝基二芳基砜1碱还原的机理.已经报道了一些这项工作.2个
DOI:10.1039/j29660000260

专利信息

专利号:US-7531694-B2
优先权日:2004-07-07
标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
发明人：VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
权利人:LUNDBECK PHARMACEUTICALS ITALY
摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

专利号:US-2008293970-A1
优先权日:2004-07-07
标 题:Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone

专利号:WO-2006002690-A1
优先权日:2004-07-07
标 题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

专利号:EP-1778630-B1
优先权日:2004-07-07
标题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

专利号:CA-2573114-C
优先权日:2004-07-07
标题:Process for synthesis of 4-4'-diamino-diphenyl-sulfone

专利号:EP-1778630-A1
优先权日:2004-07-07
标题:Process for synthesis of 4-4'-diamino-diphenyl-sulfone