CAS: 4139-61-1; 6-Bromo-4-Hydroxycoumarin

上下游产品

aluminium trichloride bis(4-bromophenyl) malonate 5-Bromo-2-hydroxyacetophenone Diethyl carbonate H-thiazol-2-ylidene)-but-2-enylidene]-chroman-2,4-dione6-bromo-3-[4-(3-methyl-4-phenyl-3H-thiazol-2-ylidene)-but-2-enylidene]-chroman-2,4-dione H-thiazol-2-ylidene)-ethylidene]-chroman-2,4-dione6-bromo-3-[2-(3-methyl-4-phenyl-3H-thiazol-2-ylidene)-ethylidene]-chroman-2,4-dione 6-bromo-4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

4-溴苯基乙酸酯置于aluminum (Iii) Chloride,Sodium Hydride体系中,化学反应 9.0H,反应生成 6-溴-4-羟基香豆素
参考文献:2-氧代-2H-苯并二苯并-2-H-色烯基-5-氧代-2,5-二氢呋喃-3-羧酸酯的合成及抗炎活性.
标题:2-氧代-2H-苯并二苯并-2-H-色烯基-5-氧代-2,5-二氢呋喃-3-羧酸酯的合成及抗炎活性.
摘要:4-氯-2-氧代-2 H-亚甲基-3-甲醛(3A-G)和4-氯-2 H-亚甲基-3-甲醛(7A-H)与活化炔烃(4A-B)的环加成反应提供了2-Oxo-2 H-Chromenyl-5-Oxo-2,5-Dihydrofuran-3-羧酸盐(5A-N)和2 H-Chromenyl-5-Oxo-2,5-Dihydrofuran-3-羧酸盐(8A-P).筛选所有制备的化合物的抗炎活性.体外抗炎活性数据表明化合物5G,5I,5K-1和8F与标准化合物泼尼松龙(0.033+/-0.002 µm)相比,被测化合物对tnf-α(1.108+/-0.002,0.423+/-0.022,0.047+/-0.001,0.070+/-0.002和0.142+/-0.001 µm)有效.根据体外结果,已选择了三种化合物(5I,5K和8F)用于体内实验,在lps诱导的小鼠模型中,就抗炎活性而言,这些化合物被确定为更好的化合物.化合物5
DOI:10.1016/j.Bmcl.2020.127341

专利信息

专利号:US-5510375-A
优先权日:1993-11-19
标 题 :Coumarin derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN M; HAGEN SUSAN E; LUNNEY ELIZABETH; TAIT BRADLEY D
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel coumarin derivatives and related compounds which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The coumarin derivatives are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized coumarins and of related structures.

专利号:CN-112517060-A
优先权日:2020-12-02
标题:Catalyst, application and synthesis method of 4-hydroxycoumarin derivatives

专利号:CN-112517060-B
优先权日:2020-12-02
标 题 :Catalyst, application and synthesis method of 4-hydroxycoumarin derivatives