CAS: 39668-74-1; Ethyl 2-(2-Isopropyl-5-Methylcyclohexanecarboxamido)Acetate

📜碳酸氢钠,甘氨酸乙酯盐酸盐,5-甲基-2-(1-甲基乙基)-环己烷羰基氯化物置于乙醚,Magnesium Sulfate体系中,用 水,乙醚 作为反应溶剂,化学反应 2.0H,以to Yield N-P-Menth-3-Oylglycine Ethyl Ester,Bp. 150-2°/0.1 Mm的收率获得产物n-[[5-甲基-2-(异丙基)环己基]甲酰]甘氨酸乙酯
参考文献:N-Substituted Paramenthane Carboxamides
标题:N-Substituted Paramenthane Carboxamides
摘要:本发明揭示了一种对皮肤具有生理降温作用的新化合物.这些化合物是n-取代的p-薄荷烷-3-羧酰胺.

专利信息

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-2019276389-A1
优先权日:2015-12-18
标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
发明人：WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

专利号:US-8754259-B2
优先权日:2008-08-15
标 题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products
发明人：YELM KENNETH EDWARD; BUNKE GREGORY MARK; HAUGHT JOHN CHRISTIAN
权利人:PROCTER & GAMBLE; PROCTER & GAMBLE
摘要:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

专利号:WO-2017070418-A1
优先权日:2015-10-22
标 题:Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products

专利号:CA-2731967-A1
优先权日:2008-08-15
标 题:Synthesis of cyclohexane derivatives useful as sensates in consumer products

专利号:EP-3365324-A1
优先权日:2015-10-22
标题:Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products