CAS: 383-50-6; 2-Fluoroethyl 4-Methylbenzenesulfonate

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CAS号371-62-0 2-氟乙醇 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号1207989-43-2 2-fluoroethyl 4... | CAS号104-15-4 对甲苯磺酸 | CAS号4124-41-8 对甲苯磺酸酐 | CAS号6315-52-2 亚乙基二(p-甲苯磺酸盐) | CAS号657-83-0 4-methylphenyls... | CAS号194351-12-7 1-(2'-FLUORO)ET... | CAS号184042-58-8 1-(2'-FLUORO)ET... | CAS号2967-92-2 4-(2-氟乙氧基)苯甲醛 | CAS号286-20-4 环氧环己烷 | CAS号126434-51-3 (1R,2R)-1-fluor... | CAS号624-72-6 1,2-二氟乙烷 | CAS号332-47-8 1-溴-4-(2-氟乙氧基)苯 | CAS号462-31-7 Thioacetic acid... | CAS号405-97-0 (2-FLUOROETHOXY...

📜4-Methylphenylsulfur Trifluoride置于间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,化学反应 5.0H,反应生成对甲苯磺酸氟乙酯
参考文献:作为有用的氟化剂的芳基氯四氟化碳:脱氧和脱硫氧氟化
标题:作为有用的氟化剂的芳基氯四氟化碳:脱氧和脱硫氧氟化
摘要:描述了芳基硫磺四氟氯化物1作为通用的脱氧和脱氟的氟化剂的用途.已经开发了两种方便的方法,用于从1原位制备反应性芳基三氟化硫2.一个是减少的1带减速器如吡啶至2,并且另一个是歧化1与二芳基二硫化物,以2与氯气的演化.后一种方法是从1获得纯净2的便捷方法.在原位制备2氟化多种底物,例如醇,醛,酮,二酮和羧酸,以高收率得到相应的cf,Cf 2,Cf 2 Cf 2和cf 3化合物.2还氟化了包括c S基团在内的各种硫化合物,以高收率得到cf 2,ocf 2,Cf 3和ocf 3化合物.的反应2与二醇或二(三甲硅烷基)二醇的衍生物或氨基醇以高收率提供相应的deoxofluoro-Arylsulfinylation产品.另外,已经发现四氟化氯1直接和有效地与硫化合物反应,以高收率得到相应的氟化合物.由于它们是生产工业上有用的五氟化芳基硫的中间体,因此芳基氯化四氟1特别是苯基硫氯化四氟(1A)有望用作廉
Doi:10.1016/j.Jfluchem.2012.03.008

专利信息

专利号:US-2016222024-A1
优先权日:2013-09-20
标 题:S-enantiomer of tetracyclic indole derivative as pbr ligands
发明人：TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER
权利人:GE HEALTHCARE LTD
摘要:The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known TSPO-binding radiotracers. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said precursor compound. Other aspects of the invention include a method for the synthesis of the in vivo imaging agent of the invention comprising use of the precursor compound of the invention, a kit for carrying out said method, and a cassette for carrying out an automated version of said method. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.

专利号:US-2012189547-A1
优先权日:2009-10-08
标 题 :[18f] labelled analogues of flumazenil as in vivo imaging agents
发明人：WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
权利人:WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
摘要:The present invention provides radiofluorinated compounds useful for in vivo imaging GABA A receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automated method of synthesis. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention.

专利号:US-2005232387-A1
优先权日:2004-04-20
标题:Microfluidic apparatus and method for synthesis of molecular imaging probes
发明人：PADGETT HENRY C; BUCHANAN CHARLES R; COLLIER THOMAS L; MATTEO JOSEPH C; ALVORD CHARLES W
权利人:PADGETT HENRY C; BUCHANAN CHARLES R; COLLIER THOMAS L; MATTEO JOSEPH C; ALVORD CHARLES W
摘要:The invention provides a method and apparatus for preparation of radiochemicals, such as PET molecular imaging probes, wherein the reaction step or steps that couple the radioactive isotope to an organic or inorganic compound to form a positron-emitting molecular imaging probe are performed in a microfluidic environment. The method for synthesizing a radiochemical in a microfluidic environment comprises: i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port; ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor; iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor; v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, the reacting step resulting in formation of a radiochemical; and vi) collecting the radiochemical from the outlet port of the micro reactor.

专利号:US-9481685-B2
优先权日:2008-10-02
标 题:Imaging neuroinflammation
发明人：WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN
权利人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; GE HEALTHCARE LTD
摘要:The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.

专利号:US-9220795-B2
优先权日:2011-09-22
标题 :Indole derivatives
发明人：WADSWORTH HARRY JOHN; O'SHEA DENNIS; PASSMORE JOANNA; TRIGG WILLIAM; EEWAN AMANDA; SHAN BO
权利人:GE HEALTHCARE LTD
摘要:An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.

专利号:US-8790619-B2
优先权日:2009-03-27
标题 :Indole derivatives
发明人：WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; EWAN AMANDA
权利人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; EWAN AMANDA; GE HEALTHCARE LTD
摘要:An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.