CAS: 3724-43-4; (Chloromethylene)Dimethyliminium Chloride

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CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号88-95-9 邻苯二甲酰氯 | CAS号79-37-8 草酰氯 | CAS号75-44-5 光气 | CAS号32315-10-9 三光气 | CAS号346-55-4 4-氯-7-(三氟甲基)喹啉 | CAS号3934-20-1 2,4-二氯嘧啶 | CAS号16849-88-0 二甲胺亚甲基丙二腈 | CAS号4771-48-6 4-甲基吲哚-3-甲醛 | CAS号51076-46-1 2-(4-吡啶)丙二醛 | CAS号80645-64-3 1-(N,N-Dimethyl... | CAS号557795-19-4 舒尼替尼 | CAS号14758-19-1 1,3-dichloro-N,... | CAS号485-72-3 芒柄花黄素 | CAS号4887-82-5 5-氯苯并咪唑

📜N,N-二甲基甲酰胺二甲基缩醛置于草酰氯体系中,用 二氯甲烷 用作溶剂,化学反应 5.0H,反应生成(氯亚甲基)二甲基氯化铵
参考文献:温和条件下苄炔[4+2]环加成合成4-取代的2-(三氯甲基)喹唑啉
标题:温和条件下苄炔[4+2]环加成合成4-取代的2-(三氯甲基)喹唑啉
摘要:开发了通过苄与 2-(三氯甲基)-1,3-二氮杂丁二烯的环加成在实验上简单方便地合成 4-取代的 2-(三氯甲基) 喹唑啉.2-(三氯甲基)-1,3-二氮杂丁二烯(r1 = H 和 Me)由三氯乙脒和适当的 N,N-二甲基酰胺二甲基乙缩醛或三氯乙脒和含有芳基的 Vilsmeier-Haack 试剂制备.
Doi:10.1002/ejoc.201402706

专利信息

专利号:WO-2024185734-A1
优先权日:2023-03-03
标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide
发明人：KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma
权利人:NATIAS INC
摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.

专利号:US-5191087-A
优先权日:1991-07-24
标 题 :Process for the synthesis of 1,4-disubstituted pyrazoles
发明人：ALCARAZ JEAN-MARIE; LECACHEUR MARYSE; ROBIN YVES
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of 1,4-disubstituted pyrazoles. A monosubstituted hydrazine is reacted with the product of reaction of an acetal with an N-substituted halomethyliminium salt, preferably N,N-dimethylchloromethyliminium chloride. n The 1,4-disubstituted pyrazoles are, in particular, important intermediates in the synthesis of herbicides or drugs.

专利号:US-5387681-A
优先权日:1992-08-19
标题:Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides
发明人：MILLER WILLIAM D; TAO EDDIE V P
权利人:LILLY CO ELI
摘要:This invention provides a novel process for the synthesis of bicyclic aromatic sulfonic acids employing reacting a bicyclic aromatic compound with sulfur trioxide-N,N-dimethylformamide complex in the presence of a water miscible, non-reactive solvent. The resulting sulfonic acid may be converted into the corresponding sulfonyl halide by the reaction with a thionyl halide. This invention further provides a novel process for the synthesis of bicyclic aromatic sulfonamides employing the reaction conditions described supra followed by an ammonolysis or amination.

专利号:US-8871975-B2
优先权日:2011-01-05
标题 :Process for the synthesis of agomelatine
发明人：ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI
权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I)

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:US-4943630-A
优先权日:1982-10-27
标题 :Method for carrying out the organic synthesis of oligosaccharides containing galactosamine-uronic acid patterns, new oligosaccharides obtained and biological applications thereof
发明人：JACQUINET JEAN-CLAUDE; PETITOU MAURICE; SINAY PIERRE; CHOAY JEAN
权利人:CHOAY SA
摘要:Process for the organic synthesis of oligosaccharides forming or corresponding to fragments of acid mucopolysaccharides wherein two compounds comprised of or terminated respectively by patterns of galactosamine structure and patterns of uronic acid structure. Said patterns are specifically substituted. Said process results in oligosaccharides usable particularly in therapy.