CAS: 3690-12-8; (4-Amino-2-Methoxypyrimidin-5-yl)Methanol

上下游产品

4-氨基-2-甲氧基-5-嘧啶甲腈 4-Amino-2-Methoxy-Pyrimidine-5-Carbonitrile 6964-55-2
2-羟基-4-氨基-5-羟甲基嘧啶 5-Hydroxymethylcytosine 1123-95-1

📜4-氨基-2-甲氧基-5-嘧啶甲腈置于palladium On Activated Charcoal 硫酸,氢气体系中,化学反应 3.0H,以53%的收率获得产物4-氨基-2-甲氧基-5-嘧啶甲醇
参考文献:由氨基嘧啶甲醛合成吡啶并[2,3-D]嘧啶
标题:由氨基嘧啶甲醛合成吡啶并[2,3-D]嘧啶
摘要:2-甲氧基-4-氨基-5-Pyrimidinecarbaldehyde(2A),以及它的6-甲基2B和6-苯基衍生物2C中通过还原相应的aminopyrimidinecarbonitriles制备1.1A,1B的催化加氢得到5-羟甲基嘧啶3A,3B; N = 1.在相同条件下1C得到5-氨基甲基嘧啶4.2与带有-Ch 2 Co-部分的腈,酮和多官能羰基化合物缩合,得到吡啶并[2,3-D]嘧啶和嘧啶并-[4,5-B]喹啉衍生物.
DOI:10.1002/jhet.5570350226

专利信息

专利号:WO-2022146324-A1
优先权日:2020-12-29
标 题 :Synthesis of pyrimidine-4(lh)-one derivatives from new hydrazineylidene
发明人：SARIPINAR EMIN; BURCU HILAL JANSET; KEKEÇMUHAMMED HÃœSEYIN; TAPERA MICHAEL
权利人:T C ERCIYES UENIVERSITESI
摘要:This invention relates to the synthesis of pyrimidine-4 (1H)-one derivatives from Meldrum's acid, carbonyl compounds (aldehyde/ketone), and guanylhydrazone derivatives and tautomers, enantiomers, and salts thereof.

专利号:TR-2021011437-A2
优先权日:2020-12-29
标题 :SYNTHESIS OF PYRIMIDIN-4(1H)-ON DERIVATIVES FROM NEW HYDRAZINELIAN

专利号:US-2009209554-A1
优先权日:2004-03-24
标题 :Thiazoliums as transketolase inhibitors
发明人：BOYD STEVEN A; CONDROSKI KEVIN R; DE MEESE JASON; GONZALES STEPHEN S; GUNAWARDANA INDRANI W; KAPLAN TOMAS; HUEROU YVAN LE; LYSSIKATOS JOSEPH; ROMOFF TODD T; SULLIVAN FRANCIS X; THOMAS ALLEN
权利人:ARRAY BIOPHARMA INC
摘要:The present invention provides N-3′-pyridyl-methyl or N-2′-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R 1 , R 2 , R 3 , Y, R 5 -R 9 , R a -R d , n and X − are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.