CAS: 3546-03-0; 10-(3-(Dimethylamino)-2-Methylpropyl)-10H-Phenothiazine-2-Carbonitrile

上下游产品

Cyamemazine N-Oxide 1366180-94-0
(±)-2-Chloro-10-(3-Dimethylamino-2-Methylpropyl)Phenothiazine 20828-91-5
2-氰基吩噻嗪 2-Cyanophenothiazine 38642-74-9
10H-吩噻嗪-2-羧酸酰胺 Phenothiazine-2-Carboxamide 1778-82-1
10H-吩噻嗪-2-羧酸 2-Carboxyphenothiazine 25234-50-8

📜2-氯吩噻嗪置于nickel(II) Iodide,三甲基溴硅烷,三(三甲基硅基)硅烷,四丁基溴化铵,1,8-二氮杂双环[5.4.0]十一碳-7-烯,4,4'-二叔丁基-2,2'-二吡啶,Sodium Hydroxide体系中,用 甲苯 用作溶剂,化学反应 26.0H,反应生成氰美马嗪
参考文献:芳基卤化物的光化学启用的镍催化氰化
标题:芳基卤化物的光化学启用的镍催化氰化
摘要:报道了使用 1,4-二氰基苯作为氰化剂的光促进 Ni 催化的芳基卤化物氰化反应.广泛的芳基溴化物,氯化物和药物样分子可以转化为相应的腈(65 个例子).机理研究表明,在辐照下,氧化加成产物 Ni(II)(Dtbbpy)( P-C 6 H 4 Cn)(Cn) 发生 Ni-芳基键均裂,生成芳基自由基和 Ni(I)-Cn 物质,后者引发随后的氰化反应.
Doi:10.1021/acs.Orglett.2C00203

专利信息

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:US-9580409-B2
优先权日:2011-11-07
标 题:Modulators of opioid receptors and methods of use thereof
发明人：MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-11459325-B2
优先权日:2018-01-31
标题:Heterocyclic compound
发明人：TANAKA YUTA; OHASHI TOMOHIRO; IKEDA ZENICHI; TANAKA YUTA; PÃœNNER FLORIAN; YAMAMOTO TAKESHI; KAKEGAWA KEIKO; KIKUCHI FUMIAKI; MORISHITA NAO; KASAHARA TAKAHITO; SETO MASAKI; NAKAMURA MINORU; TAKAMI KAZUAKI; MURAKAMI MASATAKA; DAINI MASAKI; MIKAMI SATOSHI; SASAKI MINORU
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like. n The present invention relates to a compound represented by the formula (I): n nwherein each symbol is as described in the specification, or a salt thereof.

专利号:WO-2025118034-A1
优先权日:2023-12-06
标题 :Compounds active at the serotonergic 5-ht2a receptor
发明人：JORGENSON WILLIAM; TAN JINLONG; WHISH LACHLAN; BANISTER SAMUEL
权利人:Psylo Pty Ltd
摘要:The present disclosure relates to compounds of formula (I), their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.

专利号:WO-2023230649-A1
优先权日:2022-05-30
标题:Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates to compounds of formula (I), their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.

专利号:US-12415804-B2
优先权日:2023-06-28
标题 :Compounds for activating a serotonin receptor
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.