专利号:WO-2025104624-A1 优先权日:2023-11-14 标题 :Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol 发明人:ALEXANDER KATY LOUISE; ANSARI ZARRIN FAZAL KHADIJA; DANIELS DAVID SYDNEY BERNARD; HASSEL LUKE HARRY; KEEN STEPHEN PHILIP; SCOTT JEREMY PETER; SCOTT REUBEN JOHN; SIMMONS JOHATHAN ANDREW; STOLL EMMA LOUISE; TRINDADE ALEXANDRE FONSECA; VICINI ANNA CHIARA 权利人:PFIZER 摘要:This disclosure relates novel methods to prepare 1,5-anhydro-3-({5-chloro-4-[4- fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2- yl}amino)-2,3-dideoxy-D-threo-pentitol, and hydrates and stereoisomers thereof, as well as intermediates, including solid forms of the intermediates, useful for the preparation of such compounds and the synthesis of said intermediates.
专利号:US-5504229-A 优先权日:1993-08-10 标题 :Synthesis of aliphatic C2 -C22 carboxylic acids 发明人:FISHER KARL; FRITZ GERHARD 权利人:BASF AG 摘要:Synthesis of aliphatic C 2 -C 22 carboxylic acids by oxidation of relevant aldehydes with oxygen in the presence of alkali metal compounds or alkaline earth metal compounds in the liquid phase and separation of the reaction mixture by distillation, in which the bottom product formed during distillation and containing an alkali metal salt or alkaline earth metal salt is recycled to the oxidation stage.
专利号:US-9611352-B2 优先权日:2014-09-17 标 题:Synthesis and molecular weight control of aliphatic polyester diols 发明人:NARINE SURESH; LI SHAOJUN; JOSE JESMY; SHETRANJIWALLA SHEGUFTA; BOUZIDI LAZIZ 权利人:UNIV TRENT 摘要:The synthesis of certain polyester diols (PEDs) is disclosed. This application also discloses the purification and polymerization kinetics of lipid based PEDs. Molecular weight and distribution controls were achieved by initial and induced stoichiometric imbalance and optimization of the purification protocol. Thermal degradation and thermal transition behavior of the PEDs were also investigated by TGA and DSC.
专利号:US-4283531-A 优先权日:1978-06-02 标 题:Synthesis of β-lactams having a substituted hydroxymethylene group at the position α to the lactam carbonyl group 发明人:GANGULY ASHIT K; GIRIJAVALLABHAN VIYYOOR M; CAVENDER PATRICIA; SARRE OLGA; MCCOMBIE STUART W 权利人:SCHERING CORP 摘要:β-Lactams having a substituted hydroxymethylene group at the position α to the lactam carbonyl group are prepared by reaction of an α-halo-β-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone. n Also described are novel penicillins and cephalosporins having useful antibacterial activity.
专利号:US-6033551-A 优先权日:1997-11-19 标 题:Synthesis of metal 2-ethylhexanoates 发明人:KOVSMAN E P; YANOVSKAYA M I; SOLDATOV B G; MOZAK G V 摘要:A process for synthesizing metal 2-ethylhexanoates includes reaction of metals with a reaction mixture including a carboxylic acid, a low weight aliphatic alcohol, and an electroconductive additive under the action of electric current in an elecrolyzer. In the electrolyzer, an ion exchange membrane divides respective anode and cathode compartments. The metal is introduced in the form of an anode, and is preferably lead or bismuth. The carboxylate is preferably 2-ethylhexanoic acid. The electroconductive additive is preferably a salt of 2-ethylhexanoic acid and an alkali metal or ammonium cation.
专利号:RU-2135502-C1 优先权日:1993-03-26 标 题:Clavulanic acid diamine salts, method of their synthesis (variants), method of synthesis of clavulanic acid or its pharmaceutically acceptable salt, method of purification of clavulanic acid of its salt