CAS: 3073-59-4; N,N'-(Hexane-1,6-Diyl)Diacetamide

该化合物其结构特征为六甲基苯链,连接两个乙酰胺组,通常是室内温度的白色晶状固体,在水和酒精等极溶剂中可溶解.六甲基乙酰乙酰胺以其作为催化剂的能力而著称,经常用于聚合物和树脂的生产,提高其灵活性和耐久性.此外,它还用于合成各种化学中间体,并可用作有机合成的再剂.复合物具有中度毒性,在处理时应采取适当的安全措施.其熔点和沸点可因纯度和环境条件而变化,但在标准实验室条件下一般保持稳定.总的来说,六甲基乙酰乙酰胺是一种多用途化合物,在工业和研究环境中都具有重大效用.

结构式图片

上下游产品

CAS号124-09-4 1,6-己二胺 | CAS号121-44-8 三乙胺 | CAS号75-36-5 乙酰氯 | CAS号60-35-5 乙酰胺 | CAS号64-19-7 冰醋酸 | CAS号822-06-0 六亚甲基二异氰酸酯 | CAS号692-33-1 Acetamide,N-2-p... | CAS号105-74-8 过氧化十二酰 | CAS号68293-74-3 6-nitro-hexa-2,... | CAS号108-24-7 乙酸酐 | CAS号79-16-3 N-甲基乙酰胺 | CAS号60-35-5 乙酰胺 | CAS号2463-29-8 Acetamide,N,N'-... | CAS号127-19-5 N,N-二甲基乙酰胺(DMAC) | CAS号10151-12-9 Acetamide,N,N'-... | CAS号13093-05-5 N,N'-二乙基-1,6-二氨基己烷 | CAS号3066-65-7 己二氨基甲酸乙酯 | CAS号16644-57-8 Carbamic acid,N... | CAS号6030-54-2 己烷-1,6-二基二氨基甲酸二甲酯 | CAS号1206701-19-0 methyl 1,6-hexa...

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 N,N'-六亚甲基双乙酰胺
    参考文献:Bayer,Angewandte Chemie,1947,Vol. 59,P. 261
    标题:Bayer,Angewandte Chemie,1947,Vol. 59,P. 261

    海关参考信息

    专利信息


    专利号:US-8734846-B2
    优先权日:2008-06-16
    标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
    发明人:ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
    权利人:BIND BIOSCIENCES INC
    摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

    专利号:US-2013035307-A1
    优先权日:2010-01-26
    标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
    发明人:PRESTWICH GLENN D; KENNEDY THOMAS P
    权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
    摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

    专利号:US-2008214827-A1
    优先权日:2004-02-03
    标 题:Synthesis of Cyanoimino-Benzoimidazoles
    发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
    权利人:EURO CELTIQUE SA
    摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

    专利号:US-9220714-B2
    优先权日:2006-03-16
    标 题 :Nitrofuran compounds for the treatment of cancer and angiogenesis
    发明人:SAULNIER SHOLLER GISELLE L; SWAMY NARASIMHA; KALKUNTE STAYAN; SINGH RAKESH K; BRARD LAURENT; KIM KYU KWANG
    权利人:WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND; UNIV BROWN; WOMEN AND INFANTS HOSPITAL RHODE ISLAND
    摘要:The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

    专利号:US-2022064167-A1
    优先权日:2018-05-17
    标 题 :Imidazo-pyrazole carboxamide derivatives as anticancer agents and the synthesis thereof
    发明人:DEMJÉN ANDRÃ?S; Puskás László; KANIZSAI IVAN; SZEBENI GÃ?BOR; ANGYAL ANIKÓ; GYURIS Márió; Hackler László
    权利人:AVIDIN KFT
    摘要:The present invention relates to novel imidazo[1,2-b]pyrazole carboxamide and carbothioamide derivatives of general formula (V), and the advantageous derivatives and pharmaceutically acceptable salts thereof, the synthesis thereof, and medicinal and/or pharmaceutical composition comprising these compounds thereof and synthesis thereof, and for use as a medicament, for use in the treatment of different diseases, advantageously of cancer. The subject compounds are advantageously for use in the treatment of solid malignancies, advantageously breast, lung, melanoma, gliomas, and myeloproliferative and myelodysplastic neoplasms, acute myelogenous/myeloid leukemias and colon cancer by the differentiation and subsequent apoptosis of pre-matured myeloid leukemic cells or myeloid-derived suppressor cells and/or by direct effect on solid tumors.

    专利号:US-6787668-B2
    优先权日:2000-04-13
    标 题 :2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    发明人:PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
    权利人:PHARMACIA CORP
    摘要:The present invention is directed to a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from the group consisting of H and methyl; andR2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


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    摘要:Weir JP. Infection of human NT2 cells and differentiated NT-neurons with herpes simplex virus and replication-incompetent herpes simplex virus vectors. J Neurovirol. 2001 Feb;7(1):43–51. doi: 10.1080/135502801300069656.
    参考文献:10.1016/j.biocel.2004.01.021|10.1016/s1357-2725(04)00031-7
    摘要:Zhang G, Wang G, Wang S, Li Q, Ouyang G, Peng X. Applying proteomic methodologies to analyze the effect of hexamethylene bisacetamide (HMBA) on proliferation and differentiation of human gastric carcinoma BGC-823 cells. The International Journal of Biochemistry & Cell Biology. 2004 Aug;36(8):1613–23. doi: 10.1016/j.biocel.2004.01.021.
    参考文献:10.1046/j.1523-1755.2001.060003996.x
    摘要:Ogawa T, Hayashi T, Yorioka N, Kyoizumi S, Trosko JE. Hexamethylene bisacetamide protects peritoneal mesothelial cells from glucose. Kidney Int. 2001 Sep;60(3):996–1008. doi: 10.1046/j.1523-1755.2001.060003996.x.
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