CAS: 306-60-5; 1-(4-Aminobutyl)Guanidine

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CAS号2482-00-0 硫酸胍基丁胺 | CAS号23441-10-3 N-Benzyloxycarb... | CAS号74-79-3 L-精氨酸 | CAS号420-04-2 氰胺 | CAS号110-60-1 1,4-丁二胺 | CAS号14527-26-5 S-甲基异硫脲硫酸盐 | CAS号22906-75-8 3,5-二甲基吡唑-1-羧胺 | CAS号18807-73-3 N-苄氧羰基-1,4-二氨基丁烷盐酸盐 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号463-00-3 4-胍基丁酸 | CAS号113-00-8 guanidine | CAS号110-60-1 1,4-丁二胺 | CAS号57-13-6 尿素 | CAS号6851-51-0 N-carbamoylputr...

📜硫酸胍基丁胺置于四甲基氢氧化铵体系中,用 甲醇 用作溶剂,化学反应 1.0H,反应生成(4-氨基丁基)胍
参考文献:Stabilization Of Polynucleotide Complexes
标题:Stabilization Of Polynucleotide Complexes
摘要:聚核苷酸复合物通过添加一种抗冻保护剂并对所得的配方进行冻干处理来稳定.冻干配方经过研磨或筛选成为干粉配方,可用于传递聚核苷酸复合物.将聚核苷酸传递到所需细胞组织的方法是通过将粉末与组织接触以重新水合.在一个首选实施例中,使用干粉配方来诱导患者肺组织的基因修饰.

专利信息

专利号:WO-2025078505-A1
优先权日:2023-10-13
标 题 :One pot gmp scalable production method for the synthesis of dextran-guanidine-bisphosphonate conjugate
发明人：HOLMBERG ANDERS R
权利人:DEXTECH MEDICAL AB
摘要:The disclosure relates to a large scale GMP synthesis of a modified dextran conjugate, and more particularly to a dextran-guanidine-bisphosphonate conjugate wherein the bisphosphonate is an alendronate group. The disclosure relates to a large scale GMP synthesis that produces high purity, pharmaceutical grade dextran-guanidine-bisphosphonate conjugate. The present disclosure further concerns the use of said dextran-guanidine-bisphosphonate conjugate in medicines treating tumors.

专利号:US-6994986-B2
优先权日:1999-03-17
标 题:In vitro synthesis of polypeptides by optimizing amino acid metabolism
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides. In order to improve the performance of in vitro protein synthesis reactions, metabolic inhibitors, or manipulation of a source organism, is used to diminish or avoid the action of enzymes responsible for undesirable amino acids production or depletion. A homeostatic system may be used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.

专利号:US-7294743-B2
优先权日:2003-10-23
标题:Method for synthesis of acrylamide derivatives
发明人：ALGOTSSON MATTIAS; BUSSON PHILIPPE; THEVENIN NICOLAS
权利人:GE HEALTHCARE BIO SCIENCES AB
摘要:The present invention relates to a method for synthesis of an acrylamide derivative, starting with dissolving a salt of a nucleophilic amine in water to form an aqueous solution and desalting said solution with a base, comprising the following steps:n a) addition of dissolved activated acrylic acid derivative to said solution; b) acidification of aqueous phase; and c) extraction of said aqueous phase.

专利号:US-9523083-B2
优先权日:2004-07-15
标 题 :Biochemical synthesis of 1,4-butanediamine
发明人：EPPELMANN KATRIN; NOSSIN PETRUS M M; KREMER SUSANNE M; WUBBOLTS MARCEL G
权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV
摘要:Process for biochemical synthesis of 1,4-butanediannine in a microorganism having an increased level of an ornithine decarboxylase activity as compared to the native level of the ornithine decarboxylase activity, in which the increased ornithine decarboxylase activity is obtained by overexpression of an ornithine decarboxylase encoding gene with increased translational and/or transcriptional efficiency. The process is performed by excreting 1,4-butanediamine produced in the microorganism into a fermentation broth, and recovering the 1,4-butanediannine from the fermentation broth. The increased translational and/or transcriptional efficiency is obtained by the use of a strong, regulated promoter consisting of an isopropvl-B-D-thiogalactoside (IPTG) inducible strong promoter.

专利号:US-8497098-B2
优先权日:2004-07-15
标题 :Biochemical synthesis of 1,4-butanediamine
发明人：EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G
权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV
摘要:The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.

专利号:US-9394528-B2
优先权日:2004-06-29
标题 :Gene products of Bacillus licheniformis which form odorous substances and improved biotechnological production methods based thereon
发明人：BESSLER CORNELIUS; FEESCHE JÖRG; EVERS STEFAN; MAURER KARL-HEINZ; EHRENREICH ARMIN; VEITH BIRGIT; LIESEGANG HEIKO; HENNE ANKE; HERZBERG CHRISTINA; GOTTSCHALK GERHARD
权利人:BESSLER CORNELIUS; FEESCHE JÖRG; EVERS STEFAN; MAURER KARL-HEINZ; EHRENREICH ARMIN; VEITH BIRGIT; LIESEGANG HEIKO; HENNE ANKE; HERZBERG CHRISTINA; GOTTSCHALK GERHARD; BASF SE
摘要:The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.