CAS: 28314-80-9; 2,4,6-Trifluorobenzoic Acid

上下游产品

CAS号124-38-9 二氧化碳 | CAS号372-38-3 1,3,5-三氟苯 | CAS号1443144-29-3 2,4,6-trifluoro... | CAS号372-38-3 1,3,5-三氟苯 | CAS号191478-99-6 4-氨基-2,6-二氟苯甲酸甲酯 | CAS号79538-29-7 2,4,6-三氟苯甲酰氯 | CAS号189283-54-3 2,4-二氟-6-羟基苯甲酸 | CAS号79538-28-6 2,4,6-三氟苯甲酸甲酯 | CAS号934665-14-2 2,4-二氟-6-[(2-氟-...

4-Fluoro-N-(Quinolin-8-yl)Benzamide置于吡啶,Copper(L) Iodide,Silver Fluoride,N-甲基吗啉氧化物,Sodium Hydroxide体系中,用 乙醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 25.5H,反应生成2,4,6-三氟苯甲酸
参考文献:Copper-Catalyzed,Directing Group-Assisted Fluorination Of Arene And Heteroarene C-h Bonds
标题:Copper-Catalyzed,Directing Group-Assisted Fluorination Of Arene And Heteroarene C-h Bonds
摘要:We Have Developed A Method For Direct,Copper-Catalyzed,Auxiliary-Assisted Fluorination Of Beta-Sp(2) C-H Bonds Of Benzoic Acid Derivatives And Gamma-Sp(2) C-H Bonds Of Alpha,Alpha-Disubstituted Benzylamine Derivatives. The Reaction Employs A Cui Catalyst,A Agf Fluoride Source,And Dmf,Pyridine,Or Dmpu Solvent At Moderately Elevated Temperatures. Selective Mono-Or Difluorination Can Be Achieved By Simply Changing Reaction Conditions. The Method Shows Excellent Functional Group Tolerance And Provides A Straightforward Way For The Preparation Of Ortho-Fluorinated Benzoic Acids.
Doi:10.1021/ja4047125

专利信息

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:CN-111943930-A
优先权日:2020-08-25
标题 :Synthesis of Lasmiditan

专利号:CN-111943930-B
优先权日:2020-08-25
标题 :Synthesis of Lasmiditan

专利号:US-7189749-B2
优先权日:1999-06-25
标 题 :Substituted phenoxyacetic acids
发明人：VAN ZANDT MICHAEL C
权利人:INST FOR PHARM DISCOVERY INC
摘要:Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.

专利号:US-2023098051-A1
优先权日:2019-12-13
标题:Process for the preparation of lasmiditan and of a synthesis intermediate

专利号:CN-115181054-B
优先权日:2022-08-16
标 题 :Synthesis method of 3-benzyl indole compound