专利号:WO-2023086799-A1 优先权日:2021-11-09 标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists 发明人:HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P 权利人:VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:BR-112019014061-A2 优先权日:2017-01-23 标 题 :compounds of formula i, intermediates b, intermediates c, intermediates ii and intermediates d, composition, use, method to combat phytopathogenic fungi, seed and process for the synthesis of the compounds of formula i
专利号:US-2001053850-A1 优先权日:2000-05-23 标题 :Novel synthesis of heteroarylamine intermediate compounds
专利号:US-2024199548-A1 优先权日:2021-03-26 标题 :Novel compounds useful as sting agonists and uses thereof 发明人:YE YANG; LI XIUWEI; YANG GUIQUN; YAN FASHUN; WANG YANPING; LONG WEI 权利人:JACOBIO PHARMACEUTICALS CO LTD 摘要:Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
专利号:US-2025108123-A1 优先权日:2021-12-17 标 题:Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof 发明人:YE YANG; LI XIUWEI; YANG GUIQUN; WANG HONGLING; FANG XIONG; CUI YANKAI; YAN FASHUN; SONG BINHUA 权利人:JACOBIO PHARMACEUTICALS CO LTD 摘要:Provided herein are compound-linker constructs and antibody-drug-conjugates of compounds of formula (Y-1), (Y-2), (Y-3), (A), (B), (C), I, II, III, IV or V that are useful as modulators of STING (Stimulator of Interferon Genes). Also provided are synthesis, compositions and uses of such compound-linker constructs and antibody-drug-conjugates.
专利号:WO-2024115549-A1 优先权日:2022-11-30 标题:Aryl- and heteroaryl-sulfonamide derivatives as ccr8 modulators 发明人:AISSAOUI HAMED; CORMINBOEUF OLIVIER; DIETHELM STEFAN; REMEN LUBOS; RICHARD-BILDSTEIN SYLVIA 权利人:IDORSIA PHARMACEUTICALS LTD 摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR8 receptor modulators in medicine.