CAS: 22570-53-2; (3S,3As,5Ar,5Br,7S,7As,11Ar,11Br,13Ar,13Bs)-3-(2-Hydroxypropan-2-yl)-5A,5B,8,8,11A,13B-Hexamethylicosahydro-1H-Cyclopenta[a]Chrysen-7-Ol

该化合物是Euphorbiaceae家族的植物来源.Zeorin的特点是分子结构复杂,包括多环和典型的三环功能组.该化合物展示了一系列生物活动,包括潜在的抗炎和抗微生物特性,使其对药理研究感兴趣.此外,Zeorin由于存在于某些植物物种中,因此可能在植物防御机制中发挥作用.其溶解性和稳定性可能因溶剂和环境条件而不同而不同,这对于研究及潜在治疗用途都很重要.与许多自然产品一样,Zeorin的提取和净化可能具有挑战性,需要具体的方法将其有效地分离出来进行研究.

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    主要参考文献


    1: Isaka M, Sappan M, Jennifer Luangsa-Ard J, Hywel-Jones NL, Mongkolsamrit S, Chunhametha S. Chemical taxonomy of Torrubiella s. lat.: zeorin as a marker of Conoideocrella. Fungal Biol. 2011 Apr-May;115(4-5):401-5. doi: 10.1016/j.funbio.2011.02.007. Epub 2011 Feb 17. Chem Pharm Bull (Tokyo). 1966 Jul;14(7):804-7. Chinese. doi: 10.1155/2017/2079697. Epub 2017 Apr 12. Review.
    9: Isaka M, Palasarn S, Kocharin K, Hywel-Jones NL. Comparison of the bioactive secondary metabolites from the scale insect pathogens, Anamorph Paecilomyces cinnamomeus, and Teleomorph Torrubiella luteorostrata. J Antibiot (Tokyo). 2007 Sep;60(9):577-81. doi: 10.4489/MYCO.2007.35.2.045. Epub 2007 Jun 30.
    11: Bardón A, Mitre GB, Kamiya N, Toyota M, Asakawa Y. Eremophilanolides and other constituents from the Argentine liverwort Frullania brasiliensis. Phytochemistry. 2002 Jan;59(2):205-13. doi: 10.4489/MYCO.2008.36.3.190. Epub 2008 Sep 30.

    合成参考文献


    参考文献:10.1016/s0031-9422(99)00137-5
    摘要:Toyota M, Konoshima M, Yoshinori A. Terpenoid constituents of the liverwort Reboulia hemisphaerica. Phytochemistry. 1999 Sep;52(1):105–12. doi: 10.1016/s0031-9422(99)00137-5.
    参考文献:10.1248/cpb.38.2281
    摘要:WU F, KOIKE K, NIKAIDO T, ISHII K, OHMOTO T, IKEDA K. Terpenoids and flavonoids from Arenaria kansuensis. Chem. Pharm. Bull. 1990;38(8):2281–2. doi: 10.1248/cpb.38.2281.
    参考文献:10.1248/cpb.44.2213
    摘要:ITABASHI T, OGASAWARA N, NOZAWA K, KAWAI K. Isolation and Structures of New Azaphilone Derivatives, Falconensins E-G, from Emericella falconensis and Absolute Configurations of Falconensins A-G. Chem. Pharm. Bull. 1996;44(12):2213–7. doi: 10.1248/cpb.44.2213.
    参考文献:10.1248/cpb.37.2836
    摘要:INAYAMA S, HORI H, PANG G, NAGASAWA H, AGETA H. Isolation of a hopane-type triterpenoid, zeorin, from a higher plant, Tripterygium regelii. Chem. Pharm. Bull. 1989;37(10):2836–7. doi: 10.1248/cpb.37.2836.
    参考文献:10.1016/0031-9422(90)85124-x
    摘要:Bachelor FW, Kin GG, Richardson J. Phlebic acids C and D, lichen acids from Peltigera aphthosa. Phytochemistry. 1990 Jan;29(2):601–4. doi: 10.1016/0031-9422(90)85124-x.
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