CAS: 22204-53-1; (S)-2-(6-Methoxynaphthalen-2-yl)Propanoic Acid

相似化合物

23981-80-8 23979-41-1 23979-41-1

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CAS号23981-80-8 2-(6-甲氧基-2-萘基)丙酸 | CAS号23981-47-7 6-甲基萘乙酸 | CAS号51091-84-0 (S)-2-(6-甲氧基萘-2... | CAS号3900-45-6 6-甲氧基-2-乙酰萘 | CAS号52079-10-4 萘普生杂质A | CAS号7440-44-0 活性炭 | CAS号23981-80-8 2-(6-甲氧基-2-萘基)丙酸 | CAS号32725-05-6 2-Naphthaleneet... | CAS号125836-70-6 naproxen is°Cyanate | CAS号1262956-64-8 NCX 466 | CAS号26159-34-2 萘普生钠 | CAS号163133-43-5 (S)-2-(6-甲氧基-2-...

2-(6-Methoxynaphthalen-2-yl)Propionitrile置于sodium Oxide体系中,用 乙醇,水 用作溶剂,化学反应 6.0H,以85%的收率获得萘普生
参考文献:一种芳基丙酸类非甾体抗炎药的合成方法
标题:一种芳基丙酸类非甾体抗炎药的合成方法
摘要:本发明公开了一种芳基丙酸类非甾体抗炎药的合成方法,特征是以芳基乙腈类化合物作为底物,使用胺硼烷络合物,N,N‑二甲基甲酰胺作用作溶剂,在碱性条件下,经甲基化反应,得到芳基丙腈类化合物;再在强碱性条件下水解,即得到芳基丙酸类非甾体抗炎药.本发明首次使用胺硼烷络合物和n,N‑二甲基甲酰胺共同作为作为甲基化试剂,从而完全避免了使用碘甲烷,硫酸二甲酯等传统甲基化试剂所造成的双甲基化和毒性大等问题;合成方法简便,易操作,所得芳基丙酸类非甾体抗炎药产率高,纯度高.不同于以往金属催化体系,本发明方法采用的是非金属体系,从而避免了过渡金属的使用,对于避免合成药物中的金属残留提供了一种新的方法.

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-5248815-A
优先权日:1991-12-27
标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
发明人：PARADIES HENRICH H
权利人:PARADIES HENRICH H
摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.

专利号:US-2012029226-A1
优先权日:2009-02-06
标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives
发明人：KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.

专利号:US-8420850-B2
优先权日:2010-05-14
标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
发明人：DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

专利号:US-4628123-A
优先权日:1984-10-23
标题:Process for the synthesis of 2-methoxy-6-bromo-naphthalene
发明人：BORSOTTI GIAMPIERO
权利人:MONTEDISON SPA
摘要:A process for the synthesis of 2-methoxy-6-bromo-naphthalene, wherein the 2-methoxy-naphthalene is brominated by means of Br 2 to 1,6-dibromo-2-methoxy-naphthalene and the latter is then dehalogenated, without any separation from the liquid medium of reaction, by addition of iron.

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.