CAS: 211682-13-2; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-2-(Thiophen-2-yl)Acetic Acid

上下游产品

Fmoc-甘氨酸 N-(Fluoren-9-Ylmethoxycarbonyl)Glycine 29022-11-5
Fmoc-L-谷氨酸 (S)-2-[{({9H-Fluoren-9-Yl}Methoxy)Carbonyl}Amino]Pentanedioic Acid 121343-82-6
Fmoc-L-谷氨酰胺 N2-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Glutamine 71989-20-3
Fmoc-L-天冬氨酸 N-α-9-Fluorenylmethoxycarbonyl-Aspartic Acid 119062-05-4
Fmoc-L-天冬酰胺 Fmoc-Asn-Oh 71989-16-7
Fmoc-Thr-Oh 73731-37-0
Fmoc-L-亮氨酸 Fmoc-Leu-Oh 35661-60-0
Fmoc-L-酪氨酸 N-Fmoc-Tyr-Oh 92954-90-0 (S)-3-Cyclohexyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Propionic Acid 135673-97-1 S-(((9H-Fluoren-9-yl)Methoxy)Carbonyl)Cyclohexylglycine 161321-36-4

📜4-Hydroxymethylphenoxymethyl Polystyrene Resin,Fmoc-L-亮氨酸置于吡啶,2,6-二甲基-苯甲酰氯体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 20.0H,反应生成Fmoc-(R)-2-(2-噻吩基)-甘氨酸
参考文献:Amino Acid Anthranilamide Derivatives As A New Class Of Glycogen Phosphorylase Inhibitors
标题:Amino Acid Anthranilamide Derivatives As A New Class Of Glycogen Phosphorylase Inhibitors
摘要:A Series Of Amino Acid Anthranilamide Derivatives Identified From A High-Throughput Screening Campaign As Novel,Potent,And Glucose-Sensitive Inhibitors Of Human Liver Glycogen Phosphorylase A Are Described. A Solid-Phase Synthesis Using Wang Resin Was Also Developed Which Provided Efficient Access To A Variety Of Analogues,And Resulted In The Identification Of Key Structure-Activity Relationships,And The Discovery Of A Potent Exemplar (Ic(50) = 80 Nm). The Sar Scope,Synthetic Strategy,And In Vitro Results For This Series Are Presented Herein. (C) 2008 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2008.05.102