CAS: 156006-28-9; Magnesium,1,2,3-Trifluorobenzene-5-Ide,Bromide

该化合物是一种有机金属化合物,属于格里格勒试剂类别,其特点是存在三氟苯基组,与镁原子结合,而溴则作为对应物;该化合物通常由3,4,5-三氟溴苯与氢醚溶剂中的镁反应形成;该化合物具有高度反应性,特别是水分和预溶剂,导致碳氢化合物释放,并在水解过程中形成相应的酒精;三氟甲基组增强苯基环的电益性,使其成为有机合成中有价值的中间体,特别是在形成碳-碳联结时;此外,氟原子的存在可影响化合物的电子特性和再活性,使其在各种应用中有用,包括药物和农用化学.由于具有再活性,必须在惰性大气中处理,以防止分解和不想要的侧反应.

英文名称Magnesium,1,2,3-Trifluorobenzene-5-Ide,Bromide
中文名称3,4,5-三氟苯基溴化镁
IUPAC名称magnesium;1,2,3-trifluorobenzene-5-ide;bromide
其它别名3,4,5-Trifluoro-1-bromomagnesiumbenzene; 3,4,5-Trifluorophenylmagnesium bromide
CAS编号156006-28-9
MFCD编号:MFCD01311471
EINECS号:803-060-3
分子式:C6H2BrF3Mg分子量:235.29
产品CID: 775870
产品分类有机原料 → 有机金属类化合物 → 有机镁

相似结构搜索
InChIKey: FAANOBAJWDSCGM-UHFFFAOYSA-M
1S/C6H2F3.BrH.Mg/c7-4-2-1-3-5(8)6(4)9;;/h2-3H;1H;/q-1;;+2/p-1
计算化学: 氢键受体数5.0氢键供体数*可旋转键数*

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
严重眼损伤类别1
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
防范说明P210-P260-P280-P305+P351+P338-P370+P378-P403+P235
UN编号UN 2924 3/PG 2
危险品标志F,C,Xn
安全声明16-26-36/37/39-45-36/37
危险类别码11-14-19-34-40-36/37/38
WGK Germany1

欧盟法规

C&L通报

上下游产品

CAS号138526-69-9 5-溴-1,2,3-三氟苯 | CAS号7439-95-4 镁标准溶液 | CAS号59-31-4 2-羟基喹啉 | CAS号915416-45-4 3',4',5'-三氟联苯基-2-胺

合成工艺路线路线简述

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:WO-2024159724-A1
优先权日:2023-02-03
标题:O-biphenyl oxazoline compound and synthesis method therefor
发明人：ZHU JIANSHE; WANG MINGCHUN; LI QINGYI
权利人:KEYLAB JIANGSU TECH CO LTD
摘要:A synthesis method for an o-biphenyl oxazoline compound. An aryl metal compound as represent by formula II reacts with aryl oxazoline as represented by formula III to generate the o-biphenyl oxazoline compound as represented by formula I. The o-biphenyl oxazoline compound can be used for industrial preparation of o-aminobiphenyl compounds, and used for synthesizing succinate dehydrogenase inhibitor fungicides (IV) such as fluxapyroxad, bixafen, boscalid, and pyraziflumid.

专利号:CN-117486916-A
优先权日:2023-12-29
标题:A kind of synthesis method of 3,4,5-trifluorobenzene boric acid

专利号:CN-117486916-B
优先权日:2023-12-29
标题:A kind of synthesis method of 3,4,5-trifluorophenylboric acid

专利号:CN-118994044-A
优先权日:2023-06-14
标题:A kind of o-biphenyl oxazoline compound and its synthesis method

专利号:CN-109761820-B
优先权日:2019-01-25
标题:A kind of chemical synthesis method of 3',4',5'-trifluoro-[1,1'-biphenyl]-2-amine