CAS: 142404-83-9; 2-Acetylamino-3-Bromo-5-Methylpyridine

该化合物是一种化学化合物,其特征是其环,代之以溴原子和甲基组,该化合物具有乙酰功能组,表明存在碳基(C=O)结为氮原子(N).三点的溴替代物和五点方位的甲基组,有助于其独特的再活动和潜在的生物活动.乙酰胺的出现表明,该化合物可能具有亚胺的典型特性,如氢结合能力,可影响其溶性及其与生物目标的相互作用.此外,该溴原子可能增强该化合物的亲脂性并改变其药用基植物特性.

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155444-28-3 142404-82-8 7169-97-3

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CAS号17282-00-7 2-氨基-3-溴-5-甲基吡啶

合成工艺路线路线简述

    📜乙酸酐,2-氨基-3-溴-5-甲基吡啶置于溶剂黄146体系中,化学反应生成2-乙酰氨基-3-溴-5-甲基吡啶
    参考文献:Pyridine Intermediates,Useful In The Synthesis Of Beta-Adrenergic Receptor Agonists
    标题:Pyridine Intermediates,Useful In The Synthesis Of Beta-Adrenergic Receptor Agonists

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    专利信息


    专利号:EP-0842924-B1
    优先权日:1996-11-14
    标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
    发明人：WRIGHT STEPHEN WAYNE
    权利人:PFIZER
    摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

    专利号:US-6008361-A
    优先权日:1996-04-09
    标题:Substituted pyridines
    发明人：WRIGHT STEVEN W
    权利人:PFIZER
    摘要:The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certain β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R 1 , R 2 and R 4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R 1 , R 2 and Y 2* are defined herein.

    专利号:US-6031105-A
    优先权日:1996-04-09
    标题:Substituted pyridines
    发明人：WRIGHT STEVEN W
    权利人:PFIZER
    摘要:The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certian β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R 1 , R 2 and R 4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R 1 , R 2 and Y 2* are defined herein.

    专利号:ES-2203762-T3
    优先权日:1996-11-14
    标题:INTERMEDIATE PYRIDINS USEFUL IN THE SYNTHESIS OF AGONISTS OF THE BETA ADRENERGIC RECEIVER

    专利号:EP-0842924-A1
    优先权日:1996-11-14
    标题:Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists

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    主要参考文献

    参考标题:A Convenient Microwave-Assisted Arylstannane Generation-Stille Coupling Protocol
    作者:Véronique Dehlinger,Frédéric Cordier,Colin P. Dell,Nicolas Dreyfus,Nikki Jenkins,Adam J. Sanderson,Colin W. Smith |发布日期:2006.12
    摘要:An Efficient Methodology For The Synthesis Of Complex Pyridin-3-Yl-Phenyl Biaryl Systems Is Described; Microwave Irradiation Greatly Enhances The Rate Of The Two Pd-Catalyzed Key Steps: Formation Of The Stannane Partner And Its Subsequent Stille Coupling With A Range Of Highly Functionalized Pyridines. Besides Being Fast And High Yielding, This Process Also Allows Diversification Of The Pyridine At A Late Stage. (C) 2006 Elsevier Ltd. All Rights Reserved.
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