CAS: 13531-48-1; Methyl 3-Cyanobenzoate

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CAS号74-88-4 碘甲烷 | CAS号1877-72-1 3-氰基苯甲酸 | CAS号67-56-1 甲醇 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号6952-59-6 间溴苯甲腈 | CAS号201230-82-2 carbon monoxide | CAS号619-65-8 对氰基苯甲酸 | CAS号1711-11-1 3-氰基苯甲酰氯 | CAS号2905-65-9 间氯苯甲酸甲酯 | CAS号557-21-1 氰化锌 | CAS号34231-22-6 3-(氨甲基)苯甲醇 | CAS号180863-55-2 3-(((叔丁氧基羰基)氨基)... | CAS号23568-85-6 3-(2,2,2-三氟乙酰基)苯甲腈 | CAS号1877-71-0 异酞酸氢甲酯 | CAS号93071-65-9 3-(氨甲基)苯甲酸甲酯 | CAS号73096-39-6 3-(1H-四唑-5-基)苯甲酸 | CAS号52178-50-4 3-甲醛苯甲酸甲酯 | CAS号148345-63-5 3-(2H-四唑-5-基)苯甲酸甲酯 | CAS号19731-01-2 3-氰基苯并酰肼

3-(氯羰基)苯甲酸甲酯置于磷酸酐,Ammonium Hydroxide体系中,化学反应生成3-氰基苯甲酸甲酯
参考文献:Synthesis And Properties Of Some Novel Anti-Calmodulin Drugs
标题:Synthesis And Properties Of Some Novel Anti-Calmodulin Drugs
摘要:The Preparation And Properties Of Some Novel Inhibitors Of Calmodulin Function Are Described. The Compounds Are Cationic Derivatives Of Phenyl-Substituted Thiazoles Which Inhibit The Calmodulin Stimulation Of Cyclic-Amp Phosphodiesterase And Are Active Against Animal Tumor Cells In Culture. These Derivatives Form The Basis For The Preparation Of New,More Potent Inhibitors Of Calmodulin Function Which Could Take Advantage Of The Reported Elevated Levels Of Calcium-Bound Calmodulin In Tumor Cells And Show Preferential Anti-Tumor Activity. (C) 1999 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0968-0896(99)00092-9

专利信息

专利号:US-8367841-B2
优先权日:2006-09-08
标 题 :Processes for the preparation of 1,2,4-oxadiazole benzoic acids
发明人：ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J
权利人:PTC THERAPEUTICS INC; ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J
摘要:Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.

专利号:US-10189822-B2
优先权日:2015-03-19
标 题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; HEUER TIMOTHY SEAN; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-9624173-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-8129540-B2
优先权日:2003-04-11
标题:Methods for the synthesis of 1,2,4-oxadiazole benzoic acid compounds