CAS: 135-00-2; Phenyl(Thiophen-2-yl)Methanone

该化合物是一种杂交循环芳香化合物,在2位置用苯并基组取代硫苯环,这种结构具有独特的电子和化学特性,使其作为有机合成的中间体具有价值,特别是在生产药品,农用化学品和功能材料方面.它的同质系统增强了交叉反应的回弹性,而苯并基组则提供了进一步功能化的多功能性.该复合体在标准条件下表现出稳定性,并显示出与一系列反应条件的兼容性,包括电子生物替代和金属催化变异.其定义明确的分子结构使它成为设计复杂的循环框架的有用建筑块.

结构式图片

相似化合物

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合成工艺路线路线简述

    2-Bromo-5-[methoxy(Phenyl)Methyl]Thiophene置于盐酸体系中,用 二甲基亚砜 用作溶剂,化学反应 25.0H,反应生成2-苯甲酰噻吩
    参考文献:Barker,John M.; Huddleston,Patrick R.; Clephane,Janette,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 275-282
    标题:Barker,John M.; Huddleston,Patrick R.; Clephane,Janette,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 275-282

    海关参考信息

    专利信息


    专利号:US-8212056-B2
    优先权日:2008-06-30
    标 题 :Ligands for transition-metals and methods of use
    发明人:KWONG FUK YEE; SO CHAU MING
    权利人:KWONG FUK YEE; SO CHAU MING; UNIV HONG KONG POLYTECHNIC
    摘要:The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.

    专利号:US-6683205-B2
    优先权日:2001-02-15
    标 题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs
    发明人:HOSSAIN M MAHMUN
    权利人:WISYS TECHNOLOGY FOUND INC
    摘要:A method of producing a compound of the formula: n and its pharmaceutically acceptable salts, wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic group; comprising: n (1) reacting a compound of the formula: n wherein Ar is as described above, with N 2 CHCOOR, wherein R is alkyl, in the presence of a catalytic amount of a Bronsted acid or Lewis acid to form a compound of the formula: n wherein Ar and R are as described above; and n (2) reacting the compound of formula (II) with a reducing agent in the presence of an alkyl amine to form a compound of the formula: n wherein Ar and R are as described above.

    专利号:US-4845243-A
    优先权日:1986-12-23
    标 题 :Intermediates and their use in the synthesis of organic compounds
    发明人:GIORDANO CLAUDIO; CASTALDI GRAZIANO
    权利人:ZAMBON SPA
    摘要:Compounds of formula ##STR1## (wherein Ar, R, R 1 and X have the meanings reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.

    专利号:EP-0178580-B1
    优先权日:1984-10-15
    标题:Intermediates for the synthesis of carboxylic acids
    摘要:The compounds of formula: in which Ar represents an aryl, possibly substituted; R represents a C1-C4 alkyl; X represents a hydrogen, chlorine, bromine or iodine atom, a hydroxyl, or an acyloxy, alkylsulphonyloxy or arylsulphonyloxy group; n represents 0 or 1, where if n=0 one of R1 and R2 represents a -CH2OH group and the other represents a hydrogen atom, and if n=1 both R1 and R2 represent hydrogen atoms; are useful intermediates in the preparation of alpha-arylalkanoic acids by rearrangement reactions. The compounds of formula I are prepared by reacting glycerin or one of its anlogues with the appropriate alkyl-aryl-ketone.

    专利号:US-5274186-A
    优先权日:1986-12-23
    标 题 :Intermediates and their use in the synthesis of organic compounds
    发明人:GIORDANO CLAUDIO; CASTALDI GRAZIANO
    权利人:ZAMBON SPA
    摘要:Compounds of formula ##STR1## (wherein Ar, R, R 1 and X have the meaning reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.

    专利号:US-4734507-A
    优先权日:1984-04-06
    标 题:Optically active ketals, processes for their preparation and their use in the synthesis of alpha-arylalkanoic acids
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    主要参考文献


    1: Gedik Z, Tugrak M, Dastan A, Gul HI, Yilmaz D. Radiation Parameters of Some Potential Bioactive Compounds. Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Jun;35(6):1501-5. doi: 10.1080/14756360802399126.

    合成参考文献


    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 379.
    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 377.
    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 379.
    摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 115.
    摘要:Gosmini, C.; Corpet, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 706.
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