CAS: 1190-49-4; (S)-2-Amino-6-Ureidohexanoic Acid
该化合物是一种非蛋白性氨基酸,在结构上与柑橘有关,其特点是存在一个guanidino组,这是尿素循环和氮新陈代谢中涉及氨基硫的主要特征.Homictrulline通常存在于某些生物系统中,可通过蛋白质的转基因变异或代谢过程的副产品产生.众所周知,该产品在各种生理功能中发挥着作用,包括调节氮氧化物合成,这对血管健康至关重要.从溶解性角度看,同质核素一般在水中溶解,可以进行生物互动.该物质存在于生物液体中,可以表明某些代谢条件,并且可以作为特定疾病的生物标志.总体而言,同性律素是生物化学学中的一个重要化合物,有助于我们了解氨酸代谢及其在健康和疾病中的影响.
- 英文名称(S)-2-Amino-6-Ureidohexanoic Acid
- 中文名称L-高瓜氨酸
- IUPAC名称N6-carbamoyl-L-lysine
- 其它别名Lysine,N6-carbamoyl- (6CI,7CI); Lysine, N6-carbamoyl-, L- (8CI); Homo-L-citrulline; Hom°Citrulline; L-Hom°Citrulline; N-e-Carbamyl-L-lysine
- CAS编号1190-49-4
- MFCD编号:MFCD00038143
- EINECS号:214-722-0
- FDA UNII编号:133T7A0Y5K
- 分子式:C7H15N3O3分子量:189.21
- 产品CID: 253182
- 产品分类有机原料→生命科学→氨基酸及其衍生物→非蛋白质氨基酸
相似化合物
201485-17-8 372-75-8 627-77-0物理性质
MSDS等安全信息
上下游产品
CAS号57-13-6 尿素 | CAS号657-27-2 L-赖氨酸盐酸盐 | CAS号3105-95-1 L-哌啶酸 | CAS号57533-91-2 (S)-2-(((BENZYL...合成工艺路线路线简述
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水,Copper(II) Oxide体系中,化学反应生成高瓜氨酸
参考文献:Stevens; Ellman,Journal Of Biological Chemistry,1950,Vol. 182,P. 75,76
标题:Stevens; Ellman,Journal Of Biological Chemistry,1950,Vol. 182,P. 75,76
海关参考信息
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专利信息
专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:EP-3305900-A1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Turunen S, Hannonen P, Koivula MK, Risteli L, Risteli J. Separate and overlapping specificities in rheumatoid arthritis antibodies binding to citrulline- and homocitrulline-containing peptides related to type I and II collagen telopeptides. Arthritis Res Ther. 2015 Jan 9;17:2. doi: 10.1186/s13075-014-0515-z.
2: Turunen S, Koivula MK, Risteli L, Risteli J. Ureido group-specific antibodies are induced in rabbits immunized with citrulline- or homocitrulline-containing antigens. Autoimmunity. 2016 Nov;49(7):459-465. Epub 2016 Apr 21. doi: 10.1186/s13075-015-0520-x.
4: Jaisson S, Kerkeni M, Santos-Weiss IC, Addad F, Hammami M, Gillery P. Increased serum homocitrulline concentrations are associated with the severity of coronary artery disease. Clin Chem Lab Med. 2015 Jan;53(1):103-10. doi: 10.1515/cclm-2014-0642. doi: 10.1186/1479-5876-11-224.
合成参考文献
摘要:Faber, K.; Glueck, S. M., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 437.
摘要:Faber, K.; Glueck, S. M., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 438.
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