CAS: 116169-18-7; 3-Isopropyl 5-Methyl 4-(Benzo[c][1,2,5]Oxadiazol-4-yl)-2,6-Dimethylpyridine-3,5-Dicarboxylate

📜伊拉地平,置于britton-Robinson Buffer体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成异丙基甲基4-(2,1,3-苯并恶二唑-4-基)-2,6-二甲基-3,5-吡啶二羧酸酯
参考文献:Structural Effects On The Reactivity 1,4-Dihydropyridines With Alkylperoxyl Radicals And Abts Radical Cation
标题:Structural Effects On The Reactivity 1,4-Dihydropyridines With Alkylperoxyl Radicals And Abts Radical Cation
摘要:A Series Of Eight Commercial C-4 Substituted 1,4-Dihydropyridines And Other Synthesized Related Compounds Were Tested For Direct Potential Scavenger Effect Towards Alkylperoxyl Radicals And Abts Radical Cation In Aqueous Britton-Robinson Buffer Ph 7.4. A Direct Quenching Radical Species Was Established. The Tested 1,4-Dihydropyridines Were 8.3-Fold More Reactive Towards Alkylperoxyl Radicals Than Abts Cation Radical,Expressed By Their Corresponding Kinetic Rate Constants. Furthermore,Npd A Photolyte Of Nifedipine And The C-4 Unsubstituted 1,4-Dhp Were The Most Reactive Derivatives Towards Alkylperoxyl Radicals. The Pyridine Derivative Was Confirmed By Goms Technique As The Final Product Of Reaction. In Consequence,The Reduction Of Alkylperoxyl And Abts Radicals By 1,4-Dihydropyridines Involved An Electron Transfer Process. Also,The Participation Of The Hydrogen Of The 1-Position Appears As Relevant On The Reactivity. Results Of Reactivity Were Compared With Trolox. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2004.01.050