CAS: 111-50-2; Adipoyl Chloride

上下游产品

Adipic acid Dichloromethyl methyl ether bis(4-nitrophenyl)adipate 1,10-decanedioic acid 1,8-bis-diazo°Ctane-2,7-dione H,1'H-1,1'-hexanedioyl-bis-imidazole1H,1'H-1,1'-hexanedioyl-bis-imidazole Adipinoyl-bis-ε-caprolactam 1,8-bis-(1,3,3-trimethyl-indolin-2-yliden)-°Ctane-2,7-dione

己二酸置于氯化亚砜,Potassium Hydroxide体系中,用 水 用作溶剂,化学反应 1.5H,反应生成己二酰氯
参考文献:所有已知 (-)-Agelastatin 生物碱的合成和抗癌活性
标题:所有已知 (-)-Agelastatin 生物碱的合成和抗癌活性
摘要:(-)-Agelastatins A-F(我们的对映选择性全合成的全部细节1-6),描述了合成取代氮杂杂环的新方法的演变,以及所有已知 (-)-Agelastatin 生物碱对九种人类癌细胞系的首次并列评估.我们对这些生物碱的简明合成利用了合理的生物合成前体的内在化学,并利用了 C 环的后期合成.关键的铜介导的交叉偶联反应被扩展到包括基于胍的系统,提供了取代咪唑的通用制备.除了八种高级合成中间体之外,所有天然存在的 (-)-Agelastatins 的抗癌活性的直接比较使得能够对天然系列内的结构-活性关系进行系统分析.值得注意的是,(-)-Agelastatin A ( 1) 对六种血癌细胞系 (20-190 Nm) 具有高度效力,而不会影响正常红细胞 (>333 μm).(-)-Agelastatin A ( 1 ) 和 (-)-Agelastatin D ( 4 ) 是该家
Doi:10.1021/jo4020112

专利信息

专利号:US-3891594-A
优先权日:1972-04-07
标题:Direct synthesis of composite materials
发明人：TAYLOR LYNN J
权利人:TAYLOR LYNN J
摘要:There is disclosed an in situ process for the preparation of a composite material consisting essentially of an organic polymer or copolymer having dispersed therein an inorganic oxide or mixture of oxides, said process comprising the simultaneous or sequential synthesis of the organic polymer from at least one non-polymeric organic precursor and of the inorganic oxide or oxide mixture derived from at least one inorganic-oxide precursor.

专利号:US-3817911-A
优先权日:1972-04-07
标 题 :Direct synthesis of composite materials
发明人：TAYLOR L
权利人:TAYLOR L
摘要:THERE IS DISCLOSED AN IN SITU PROCESS FOR THE PREPARATION OF A COMPOSITE MATERIAL CONSISTING ESSENTIALLY OF AN ORGANIC POLYMER OR COPOLYMER HAVING DISPERSED THEREI AN INORGANIC OXIDE OR MIXTURE OF OXIDES, SAID PROCESS COMPRISING THE SIMULTANEOUS OR SEQUENTIAL SYNTHESIS OF THE ORGANIC POLYMER FROM AT LEAST ONE NON-POLYMERIC ORGANIC PRECUROR AND OF THE INORGANIC OXIDE OR OXIDE MIXTURE DERIVED FROM AT LEAST ONE INORGANIC-OXIDE PRECURSOR.

专利号:US-3960805-A
优先权日:1974-04-19
标 题:Direct synthesis of organic polymer-inorganic oxide composites
发明人：TAYLOR LYNN JOHNSTON
权利人:TAYLOR LYNN JOHNSTON
摘要:There is disclosed an in situ process for the preparation of a composite material consisting essentially of an organic polymer or copolymer having dispersed therein an inorganic oxide or mixture of oxides, said process comprising the simultaneous or sequential synthesis of the organic polymer from at least one non-polymeric organic precursor and of the inorganic oxide or oxide mixture derived from at least one inorganic-oxide precursor.

专利号:US-6090934-A
优先权日:1996-10-20
标 题:Universal support for the synthesis of oligonucleotides
发明人：KUMAR PRADEEP; GUPTA KAILASH CHAND
权利人:COUNCIL SCIENT IND RES; DBT GOVERNMENT OF INDIA
摘要:A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.

专利号:US-9303055-B2
优先权日:2001-03-14
标题 :Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
发明人：GAO XIAOLIAN; ZHANG HUA; YU PEILLIN; LEPROUST ERIC; PELLOIS JEAN PHILIPPE; XIANG QIN; ZHOU XIAOCHUAN
权利人:UNIV MICHIGAN; UNIV HOUSTON
摘要:A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.

专利号:US-10626091-B2
优先权日:2014-10-01
标 题 :Process for the preparation of enzalutamide
发明人：CHIVUKULA KAMESWAR RAO; KARUTURI VEERA VENKATESWARA RAO; BENDA SRINIVAS; ANKE RAMACHANDRA; GAJULA DHARMAPURI; MOTURU VENKATA RAMA KRISHNA MURTHY; INDUKURI VENKATA SUNIL KUMAR; GORANTLA SEETA RAMA ANJANEYULU; CHAVA SATYANARAYANA
权利人:LAURUS LABS LTD
摘要:The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.