CAS: 108-30-5; Dihydrofuran-2,5-Dione

相似化合物

4100-80-5 2170-03-8 17347-61-4

上下游产品

CAS号201230-82-2 carbon monoxide | CAS号75-56-9 环氧丙烷 | CAS号108-31-6 顺酐 | CAS号75-21-8 环氧乙烷 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号543-20-4 丁二酰氯 | CAS号111-40-0 二乙烯三胺 | CAS号57-57-8 丙内酯 | CAS号110-16-7 马来酸 | CAS号106-97-8 丁烷 | CAS号10484-48-7 4-(benzoyldioxy... | CAS号1083-11-0 4-(2,5-二甲氧基苯基)丁酸 | CAS号109591-76-6 4-oxo-4-tetrade... | CAS号109164-38-7 N-(3-氨基甲酰-4,5-二... | CAS号1083-55-2 4-oxo-4-(2-phen... | CAS号107832-33-7 (R)-(1-苯基乙基)琥珀酸酯 | CAS号108032-13-9 1,2-二棕榈酰基-sn-甘油... | CAS号4975-21-7 3,4-二甲基-1,2,5-噁二唑 | CAS号4146-43-4 丁二酸二酰肼 | CAS号35656-89-4 4-溴苯丁酸

丁二酰氯置于吡啶,三氯三氟丙酮,水体系中,用 甲苯 用作溶剂,化学反应 0.5H,以85%的收率获得丁二酸酐
参考文献:Facile Anhydride Synthesis Using Trichlorotrifluoroacetone Hydrate
标题:Facile Anhydride Synthesis Using Trichlorotrifluoroacetone Hydrate
摘要:
Doi:10.1021/jo00367A034

专利信息

专利号:US-7329515-B2
优先权日:2003-04-21
标题 :Solid support for the synthesis of 3′-amino oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified to a solid phase bound carboxylic acid and the carbonyl group is linked to an amino alcohol as an amide. Oligonucleotides are conveniently synthesized on the novel supports with no modifications in the standard phosphoramidite synthesis scheme. The ester function of the support is cleaved under the alkaline deprotection conditions for oligonucleotides to provide a free hydroxymethyl group that aids in the release of the 3′-amino oligonucleotide products with a free amino group through neighbor group participation. The free amino group of the oligonucleotides is available for further conjugation reactions to haptens, reporter groups, surfaces or other small molecules or biomolecules. The methods provided are particularly mild, do not require any modifications in standard protocols for the synthesis and deprotection of oligonucleotides, provide the 3′-amino oligonucleotides free of side products and do not introduce chiral centers to the oligonucleotides.

专利号:US-2012130699-A1
优先权日:2010-11-22
标 题 :Method of molecular design and synthesis of therapeutic and preventive drugs
发明人：MARTYNOV ARTUR; FARBER BORIS S; FARBER SONYA SOPHYA
权利人:MARTYNOV ARTUR; FARBER BORIS S; FARBER SONYA SOPHYA
摘要:Industrial Application: This invention may be used in human and veterinary medicine for the design (creation and synthesis) of therapeutic and preventive drugs that are effective for the treatment of oncological and viral human and animal illnesses and for the design of new medicines. n Summary of the Invention: A new method of design and synthesis of therapeutic and preventive drugs in which a biopolymer target (protein, DNA, RNA, or a mixture of these) is used, and in the capacity of a ligand, the same biopolymer target is used, which is cut into oligomer fragments (nucleases, synthetic nucleases, and proteases); the fragments are modified through changing their charges to the opposite charge (acylation of anhydrides of dicarbonate acids or alkylation with halogen-carbonic acids). Also in the capacity of a ligand, the same biopolymer target is used, which is modified by partially changing the molecules' charges to the opposite with the creation of supramolecular biopolymer assemblies. We used supramolecule assemblies made from oligomers that were products of the hydrolysis of biopolymers, but with a change of the charge of the molecules to the opposite charge, as well as the partial change of the charges of the target biopolymers. n Technical Result: A method of molecular design and synthesis of new, unique therapeutic and preventive drugs based on self-organizing systems. The application of the method will allow a significant cut to expenditures on the design and synthesis of new drugs, expand the activity spectra of existing protein gene-engineered drugs, and create new classes of dynamic therapeutic and preventive drugs that self-adapt to the organism and target.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-10364220-B2
优先权日:2012-12-21
标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
发明人：SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W
权利人:EXXONMOBIL CHEMICAL PATENTS INC
摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

专利号:US-9090560-B2
优先权日:2013-09-04
标 题 :Process for microwave assisted synthesis of N-methyl pyrrolidone
发明人：KHATRI PRAVEEN KUMAR; JAIN SUMAN LATA; CHATERJEE ALOK KUMAR; BIR SAIN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for microwave assisted synthesis of N-methyl pyrrolidone (NMP). Particularly the process relates to the synthesis of N-methyl succinimide or corresponding analogs by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives N-methyl pyrrolidone. Compared to the conventional heating microwave process requires less energy inputs and reduces the reaction time drastically from 5-6 h to 2-5 min.

专利号:US-2004249114-A1
优先权日:2001-02-06
标题 :Methods of synthesis of polysuccinimide or polyaspartate by end capping polymerization
发明人：SWIFT GRAHAM; REDLICH GEORGE H; WEHBY JOHN NOLAN
摘要:Disclosed are methods of synthesis of homopolymers or copolymers containing succinimide or aspartate moieties formed in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the homopolymers and copolymers.