CAS: 104-04-1; N-(4-Nitrophenyl)Acetamide

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121-95-9 122-28-1 17329-87-2

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CAS号64-19-7 冰醋酸 | CAS号100-01-6 对硝基苯胺 | CAS号108-24-7 乙酸酐 | CAS号59862-56-5 (E)-N-[1-(4-nit... | CAS号100-19-6 对硝基苯乙酮 | CAS号122-80-5 对氨基乙酰苯胺 | CAS号103-84-4 N-乙酰苯胺 | CAS号10342-64-0 1-(4-硝基苯基)乙酮肟 | CAS号1516-60-5 Benzene,1-azido... | CAS号507-09-5 硫代乙酸 | CAS号1116-24-1 N,N-二丙基乙酰胺 | CAS号100-01-6 对硝基苯胺 | CAS号77486-47-6 N'-(4-nitrophen... | CAS号10557-68-3 Acetamide,N-(4-... | CAS号3393-96-2 4'-硝基苯甲酰苯胺 | CAS号580-15-4 6-氨基喹啉 | CAS号538-41-0 对二氨基偶氮苯 | CAS号57045-86-0 N-(2-溴-4-硝基苯基)乙酰胺 | CAS号1205-59-0 Methanimidamide... | CAS号78708-10-8 (E)-3-(dimethyl...

📜N-乙酰苯胺置于硝酸,十六烷基三甲基溴化铵体系中,用 乙腈 用作溶剂,化学反应 2.0H,以85%的收率获得对硝基乙酰苯胺
参考文献:硝酸在胶束介质中硝化芳香族化合物的高效简便方法
标题:硝酸在胶束介质中硝化芳香族化合物的高效简便方法
摘要:摘要 在阴离子(十二烷基硫酸钠,Sds),阳离子(十六烷基三甲基溴化铵,Ctab)和非离子(triton-X 100)胶束存在下,使用 Hno3 在温和的反应条件下有效硝化芳族化合物.该反应迅速得到相应的单硝基衍生物,收率相当高,具有高区域选择性.这种新方法提供了一个环境安全的反应条件,以最大限度地减少废物.
Doi:10.1080/00397910802711318

专利信息

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002165398-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimers disease and schizophrenia, and infectious diseases.

专利号:WO-9635659-A1
优先权日:1995-05-12
标 题 :Amination of electrophilic aromatic compounds by vicarious nucleophilic substitution
发明人：MITCHELL ALEXANDER R; PAGORIA PHILLIP F; SCHMIDT ROBERT D
权利人:UNIV CALIFORNIA; MITCHELL ALEXANDER R; PAGORIA PHILLIP F; SCHMIDT ROBERT D
摘要:The present invention relates to a process to aminate electrophilic aromatic compounds by vicarious nucleophilic substitution of hydrogen using quaternary hydrazinium salts. The use of trimethylhydrazinium iodide, as well as hydroxylamine, alkoxylamines, and 4-amino-1,2,4-triazole to produce aminated aromatic structures, such as 1,3-diamino-2,4,6-trinitrobenzene (DATB), 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and 3,5-diamino-2,4,6-trinitrotoluene (DATNT), is described. DATB and TATB are useful insensitive high explosives. TATB is also used for the preparation of benzenehexamine, a starting material for the synthesis of novel materials (optical imaging devices, liquid crystals, ferromagnetic compounds).

专利号:US-6069277-A
优先权日:1995-05-12
标 题 :Amination of electrophilic aromatic compounds by vicarious nucleophilic substitution
发明人：MITCHELL ALEXANDER R; PAGORIA PHILIP F; SCHMIDT ROBERT D
权利人:UNIV CALIFORNIA
摘要:The present invention relates to a process to aminate electrophilic aromatic compounds by vicarious nucleophilic substitution of hydrogen using quaternary hydrazinium salts. The use of trialkylhydrazinium halide, e.g., trimethylhydrazinium iodide, as well as hydroxylamine, alkoxylamines, and 4-amino-1,2,4-triazole to produce aminated aromatic structures, such as 1,3-diamino-2,4,6-trinitrobenzene (DATB), 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and 3,5-diamino-2,4,6-trinitrotoluene (DATNT), is described. DATB and TATB are useful insensitive high explosives. TATB is also used for the preparation of benzenehexamine, a starting material for the synthesis of novel materials (optical imaging devices, liquid crystals, ferromagnetic compounds).

专利号:US-5569783-A
优先权日:1995-05-12
标 题:Vicarious nucleophilic substitution to prepare 1,3-diamino-2,4,6-trinitrobenzene or 1,3,5-triamino-2,4,6-trinitrobenzene
发明人：MITCHELL ALEXANDER R; PAGORIA PHILIP F; SCHMIDT ROBERT D
权利人:UNIV CALIFORNIA
摘要:The present invention relates to a process to produce 1,3-diamino-2,4,6-trinitrobenzene (DATB) or 1,3,5-triamino-2,4,6,-trinitrobenzene (TATB) by: n (a) reacting at ambient pressure and a temperature of between about 0° and 50° C. for between about 0.1 and 24 hr, a trinitroaromatic compound of structure V: ##STR1## wherein X, Y, and Z are each independently selected from --H, or --NH 2 , with the proviso that at least 1 or 2 of X, Y, and Z are hydrogen, n with an amount effective to produce DATB or TATB of 1,1,1-trialkylhydrazinium halide wherein alkyl is selected from methyl, ethyl, propyl or butyl and halide is selected from chloride, bromide or iodide. n in the presence of a strong base selected from sodium butoxide, potassium butoxide, potassium propoxide, sodium propoxide, sodium ethoxide, potassium ethoxide, sodium methoxide, potassium methoxide, and combinations thereof; n in a solvent selected from the group consisting of methanol, ethanol, propanol, butanol, dimethylsulphoxide, N-methylpyrrolidone, hexamethylphosphoramide, dimethylformide, dimethylacetamide and mixtures thereof, provided that when alcohols are present primarily DATB and picramide is formed; and (b) isolating the DATB or TATB produced. DATB and TATB are useful specialty explosives. TATB is also used for the preparation of benzenehexamine, a starting material for the synthesis of novel materials (optical imaging devices, liquid crystals, ferromagnetic compounds).

专利号:US-2013267712-A1
优先权日:2012-04-02
标题 :Aromatic ketone synthesis with amide reagents and related reactions
发明人：KLUMPP DOUGLAS A; RAJA ERUM K
权利人:KLUMPP DOUGLAS A; RAJA ERUM K; UNIV NORTHERN ILLINOIS
摘要:A method of preparing an aryl carbonyl or aryl thiocarbonyl compound, comprises reacting an N-(nitroaryl)-amide or N-(nitroaryl)-thioamide with an aromatic ring, with a superacid catalyst, to produce the aryl carbonyl or aryl thiocarbonyl compound. The superacid is present in an amount of at most 8 equivalents in proportion to the N-(nitroaryl)-amide or N-(nitroaryl)-thioamide. A method of preparing aryl amide or aryl thioamide, comprises reacting an N-(nitroaryl)-carbamide or N-(nitroaryl)-thiocarbamide with an aromatic ring, with a superacid catalyst, to produce the aryl amide or aryl thioamide.