CAS: 98-74-8; 4-Nitrobenzenesulfonyl Chloride

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CAS号1849-36-1 4-硝基苯硫酚 | CAS号100-01-6 对硝基苯胺 | CAS号100-32-3 4,4'-二硝基二苯二硫醚 | CAS号701-57-5 4-硝基茴香硫醚 | CAS号15119-62-7 S-(4-nitropheny... | CAS号100-05-0 4-nitrobenzened... | CAS号138-42-1 4-硝基苯磺酸水合物 | CAS号5153-67-3 反式硝基苯乙烯 | CAS号5134-88-3 对硝基苯磺酸钠 | CAS号111711-48-9 5-ethoxy-1-(4-n... | CAS号111711-83-2 1-(4-nitropheny... | CAS号109845-76-3 N-(4-methylphen... | CAS号321997-89-1 1-B°C-4-氨基哌啶-4-甲酸甲酯 | CAS号49690-09-7 N-叔丁基-4-硝基苯磺酰胺 | CAS号57-68-1 磺胺二甲嘧啶 | CAS号349-96-2 对硝基苯磺酰氟 | CAS号374783-78-5 (S)-2-甲基-1-(4-硝... | CAS号3406-75-5 2-[(4-硝基苯基)磺酰基]乙酸 | CAS号141469-52-5 N-(2-aminopheny...

4-硝基苯硫醇置于盐酸,氧气体系中,用 水,乙腈 作为反应溶剂,化学反应 24.0H,以71%的收率获得产物对硝基苯磺酰氯
参考文献:聚七嗪酰亚胺钾光催化剂色选合成磺酰氯和磺酰胺
标题:聚七嗪酰亚胺钾光催化剂色选合成磺酰氯和磺酰胺
摘要:在促进化学反应的外部刺激中,光催化有一个独特的刺激--光.光子是无痕试剂,为改变光催化反应的化学选择性(改变入射光的颜色)提供了独特的机会.该策略可以通过使用能够根据激发光激活特定反应途径的敏化剂来实现.在这里,我们使用聚七嗪酰亚胺钾(k-Phi)(一种氮化碳),只需改变激发光和其他相同的条件,即可从 S-芳基硫代乙酸盐选择性地反应生成三种不同的产物.即,芳基氯在紫外光/紫色光下产生,磺酰氯在蓝/白光下产生,二芳基二硫化物在绿光至红光下产生.带负电的聚阴离子,价带的高正电势,带内状态的存在,敏化单线态氧的能力和多电子转移的组合被证明能够实现硫代乙酸盐的这种颜色选择性转化.
DOI:10.1002/anie.202106183

专利信息

专利号:US-9988364-B1
优先权日:2017-03-21
标题 :Process for synthesis of Eliglustat and intermediate compounds thereof
发明人：LIU YU; YU GUANNENG; ZHENG ZHIGUO
权利人:ZHEJIANG AUSUN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.

专利号:US-9233943-B2
优先权日:2012-01-10
标题:Process for synthesis of syn azido epdxide and its use as intermediate for the synthesis of amprenavir and saquinavir
发明人：GADAKH SUNITA KHANDERAO; REKULA REDDY SANTHOSH; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:A novel synthetic route to the syn-azido epoxide of formula 5 includes cobalt-catalyzed hydrolytic kinetic resolution of a racemic mixture of the azido-epoxide. Reaction steps include subjecting an allylic alcohol to epoxidation with mCPBA to obtain a racemic epoxy alcohol; ring opening the epoxy alcohol with azide anion to obtain an anti-azido alcohol, which can then be selectively tosylated at the primary alcohol; treating the tosylate with base to obtain the racemic azido-epoxide; and subjecting the racemic azido-epoxide to cobalt-catalyzed hydrolytic kinetic resolution to obtain the syn-azido epoxide of formula 5. The compound of formula 5 may be used as a common intermediate for the asymmetric synthesis of HIV protease inhibitors, such as Amprenavir, Fosamprenavir, Saquinavir, and formal synthesis of Darunavir and Palinavir.

专利号:US-6639059-B1
优先权日:1999-03-24
标 题 :Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.

专利号:US-6734291-B2
优先权日:1999-03-24
标题:Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

专利号:US-6891033-B2
优先权日:2001-01-31
标题:Labelling compounds for the simple synthesis of 3'-[18F]fluoro-3'-deoxythymidine and a method for the production thereof
发明人：MARTIN STEFAN JOHANNES; EISENBARTH JOSEPH ANTONIUS MAR; WAGNER-UTERMANN ULRIKE; EISENHUT MICHAEL; MIER WALTER
权利人:DEUTSCHES KREBSFORSCH
摘要:The application relates to compounds that are suitable as labelable precursors for synthesis of 3′-[ 18 F]fluoro-3′-deoxythymidine and that have formula (1), n n nin whichn R denotes triphenylmethyl, triphenylmethyl substituted in the phenyl group, trialkylmethyl, triphenylsilyl, triphenylsilyl substituted in the phenyl group, or trialkylsilyl, R′ denotes R 1 —SO 2 , where R 1 is an unsubstituted or substituted C 1 to C 5 alkyl or an unsubstituted or substituted phenyl, and R″ denotes C 2 to C 10 alkyloxycarbonyl, with the exception of 3-N-Boc-1-(3-O-nosyl-5-O-trityl-2-deoxy-β-D-lyxofuranosy nn The application also relates to a method for preparation of these compounds and to the use of the same for synthesis of 3′-[ 18 F]fluoro-3′-deoxythymidine.