专利号:WO-2024256322-A1 优先权日:2023-06-13 标题 :Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion 发明人:LATTUADA LUCIANO; SEBASTIANO ROBERTO; LEONARDI GABRIELLA; CRAVOTTO GIANCARLO; BARGE ALESSANDRO; BUCCIOL FABIO 权利人:BRACCO IMAGING SPA; MILANO POLITECNICO 摘要:The present invention relates to the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a process for the synthesis of lopamidol using a reactive extrusion process in continuous which enable an efficient conversion of the relevant key intermediates, preferably in the absence of any solvent. The invention further relates to the preparation of radiographic X-rays contrast agents or key intermediates thereof by exploiting the technology of reactive extrusion.
专利号:US-2005209355-A1 优先权日:2004-03-22 标 题:[Novel Reactions and the Products of Such Reactions] 发明人:ROITMAN LIPA L 权利人:ROITMAN LIPA L 摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.
专利号:US-8455655-B2 优先权日:2010-05-07 标题:Preparation of dihydropyridines 发明人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH 权利人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH; LESVI LABORATORIOS SL 摘要:The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.
专利号:US-5132468-A 优先权日:1990-01-19 标题 :C-alkylation of hydroquinone or monoethers thereof 发明人:DOUSSAIN CLAUDE; GUBELMANN MICHEL; TIREL PHILIPPE-JEAN 权利人:RHONE POULENC CHIMIE 摘要:The alkyl hydroquinones, e.g., methyl hydroquinone (a useful intermediate in the preparation of the monomer methyl hydroquinone diacetate, itself used for the synthesis of thermotropic polymers), are prepared by reacting (C-alkylating) hydroquinone or a monoether thereof with a lower alkanal, in the vapor phase, with a catalytically effective amount of at least one solid metal oxide.
专利号:US-10982047-B2 优先权日:2016-09-28 标 题 :Solvent systems for synthesis of poly(amic acid) and polyimide polymers 发明人:KIM EUNGKYU; HARRIS WILLIAM J; JIANG QI; JIANG XIN; OHBA KAORU 权利人:DOW GLOBAL TECHNOLOGIES LLC 摘要:The process for synthesizing a poly(amic acid) polymer or a polyimide polymer is improved by using a solvent system consisting essentially of: (A) a first component consisting essentially of at least one of a sulfoxide, e.g., DMSO, and an alkyl phosphate, e.g., triethyl phosphate, and (B) optionally, a second component consisting essentially of at least one aprotic glycol ether, e.g., dipropylene glycol dimethyl ether.
参考文献:10.1007/978-3-662-49218-5_617 摘要:Wohlfarth C. Viscosity of the binary liquid mixture of methanol and dipropylene glycol dimethyl ether. 2017. In: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures. 参考文献:10.1007/978-3-030-69621-4_3 摘要:Aliyev IA, Trofimov BA, Oparina LA. Aromatic Disulfides, Sulfoxides, Sulfones, and Other Derivatives of Aromatic Thiols. 2021. In: Aromatic Thiols and Their Derivatives. 参考文献:10.1007/978-3-662-49218-5_981 摘要:Wohlfarth C. Viscosity of the binary liquid mixture of propan-1-ol and dipropylene glycol dimethyl ether. 2017. In: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures. 参考文献:10.1007/978-3-662-49218-5_1881 摘要:Wohlfarth C. Viscosity of the binary liquid mixture of dipropylene glycol dimethyl ether and dibutylamine. 2017. In: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures. 参考文献:10.1007/s10965-023-03767-7 摘要:Zhou B, Cao Y, Lu S, Wei J. Novel waterborne polymeric crosslinkers containing blocked isocyanate moieties and active epoxy groups for electrophoretic coatings. J Polym Res. 2023 Sep 12;30(10). doi: 10.1007/s10965-023-03767-7.