CAS: 885101-89-3; 3-(4-((3-Phenoxybenzyl)Amino)Phenyl)Propanoic Acid

上下游产品

CAS号2393-17-1 3-(4-氨基苯基)丙酸 | CAS号39515-51-0 间苯氧基苯甲醛 | CAS号16642-79-8 3-(4-硝基苯基)丙酸

📜3-(4-硝基苯基)丙酸,间苯氧基苯甲醛 反应生成 3-(4-((3-苯氧基苄基)氨基)苯基)丙酸
参考文献:Solid Phase Synthesis And Sar Of Small Molecule Agonists For The Gpr40 Receptor
标题:Solid Phase Synthesis And Sar Of Small Molecule Agonists For The Gpr40 Receptor
摘要:The Discovery,Synthesis And Structure-Activity Relationship (Sar) Of Novel Carboxylic Acid Agonists For Gpr40 Are Described. Aryl Propionic Acid 1,Identified From A High Throughput Screen,Was Selected For Chemical Exploration. Compound 2 Was Identified As Our Lead Molecule Through Efficient Solid Phase Combinatorial Array Chemistry And Had An Attractive In Vitro And In Vivo Pharmacokinetic Profile In Rat. These Ligands May Prove Useful In Establishing A Role For Gpr40 In Insulin Regulation. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2006.12.084

专利信息

专利号:US-10125101-B2
优先权日:2016-11-28
标题:Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
发明人：ECKHARDT MATTHIAS; WAGNER HOLGER; PETERS STEFAN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are as defined herein, which compounds have valuable pharmacological properties, in particular their ability to bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular type 2 diabetes. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:US-10538490-B2
优先权日:2016-10-25
标题:Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
发明人：ECKHARDT MATTHIAS; PETERS STEFAN; WAGNER HOLGER
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are defined herein, which have valuable pharmacological properties, including binding to the GPR40 receptor and modulating its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:US-9617251-B2
优先权日:2015-08-07
标题:Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
发明人：ECKHARDT MATTHIAS; PETERS STEFAN; WAGNER HOLGER
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:CN-108434151-A
优先权日:2008-01-11
标题 :Synthesis of triterpenoids and method for treating diseases

专利号:CN-104739841-B
优先权日:2008-01-11
标题:Synthesis of triterpenoids and method for treating diseases

专利号:US-9771379-B2
优先权日:2015-09-24
标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.