CAS: 80506-64-5; Amino Polyethylene Glycol Monomethyl Ether-Average M.W. 2000

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16-azido-2,5,8,11,14-pentaoxahexadecane 3,6,9,12,15-pentaoxahexadecanol 3,6,9,12,15-pentaoxahexadecyl tosylate 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-3-phenoxypyrrole-2,5-dione

三缩四乙二醇置于4-二甲氨基吡啶,氯化亚砜,Sodium Azide,Palladium 10% On Activated Carbon,水,氢气,Sodium Hydride,三乙胺,三苯基膦,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,水,N,N-二甲基甲酰胺,Mineral Oil 作为反应溶剂,80.0 °C,3.0 Mpa 条件下,反应 18.0H,反应生成 氨基十三甘醇单甲醚
参考文献:Development Of A Scalable Process For α-Amino-ω-Methoxyl-Dodecaethylene Glycol
标题:Development Of A Scalable Process For α-Amino-ω-Methoxyl-Dodecaethylene Glycol
摘要:We Have Developed A Process For The Efficient And Scalable Preparation Of Heterofunctionalized Dodecaethylene Glycol From The Readily Available Tetraethylene Glycol And Its Macrocyclic Sulfate. By Employing The Benzyl Group As Both A Protecting Group And A Separative Tag,Multiple Chromatographic Separations Were Avoided. With This Method,Alpha-Amino-Omega-Methyl-Dodecaethylene Glycol Was Prepared On A 53 G Scale With High Purity And 61% Overall Yield In Eight Steps And One Chromatographic Separation.
DOI:10.1021/acs.Oprd.5B00270