专利号:US-12180188-B2 优先权日:2020-05-19 标题:Antifibrotic compounds and related methods 发明人:STEFANOVIC BRANKO; NEFZI ADEL 权利人:UNIV FLORIDA STATE RES FOUND; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES 摘要:This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:US-5614629-A 优先权日:1995-01-30 标 题:Benzyl quaternary tropinium compound 发明人:VALYOCSIK ERNEST W 权利人:MOBIL OIL CORP 摘要:This invention is directed to novel benzyl quaternary ammonium compounds and their synthesis. The compounds have valuable utility as organic directing agents in the crystallization of a silicate structure which, in turn, is useful as a catalyst component, sorbent, and/or ion-exchanger. More particularly, this invention is concerned with benzyl quaternary ammonium compounds synthesized by selective alkylation of the bridgehead nitrogen of tropane or quinuclidine with a benzyl salt.
专利号:RU-2122999-C1 优先权日:1991-12-23 标 题:Tetrahydroisoquinoline compounds or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of dophamine receptor binding
专利号:US-6464956-B1 优先权日:2001-07-13 标题:Zeolite SSZ-59 composition of matter and synthesis thereof 发明人:ELOMARI SALEH 权利人:CHEVRON USA INC 摘要:The present invention relates to new crystalline zeolite SSZ-59 prepared using a N-methyl-N-[(1-phenylcyclopentyl)methyl]heptamethyleneiminium cation, N-methyl-N-[(1-(4-chlorophenyl)cyclopentyl)methyl]heptamethyleneiminium cation, N-methyl-N-[(1-(4-chlorophenyl)cyclopentyl)methyl]hexamethyleneiminium cation, N-methyl-N-[(1-phenylcyclopentyl)methyl]hexamethyleneiminium cation, N-methyl-N-[(1-phenylcyclopentyl)methyl]piperidinium cation or N-methyl-N-[(1-(4-chlorophenyl)cyclopentyl)methyl]piperidinium cation templating agent, and processes employing SSZ-59 as a catalyst.