专利号:US-6350875-B1 优先权日:1999-08-16 标 题:Synthesis of cyclooctatetraene derivatives and their use as electron transporters in organic light emitting diodes 发明人:WEBER WILLIAM P; LU PING; THOMPSON MARK E; HONG HAIPING 权利人:UNIV SOUTHERN CALIFORNIA 摘要:The synthesis of asymmetric tetrasubstituted cyclooctatetraenes (“COTsâ€?) and the use of said compounds in organic light emitting diodes is reported, wherein said COTs represent a class of wide gap electron transporters that are readily deposited in vacuum.
专利号:US-9273023-B2 优先权日:2011-11-01 标 题:Modular synthesis of graphene nanoribbons and graphene substructures from oligo-alkynes 发明人:ALABUGIN IGOR; BYERS PHILIP M 权利人:UNIV FLORIDA STATE RES FOUND 摘要:A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.
专利号:US-10829792-B2 优先权日:2017-03-21 标 题 :Biocatalytic synthesis of strained carbocycles 发明人:CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.
专利号:US-2005130221-A1 优先权日:2001-02-01 标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents 发明人:FLYNN BERNARD L; HAMEL ERNEST 权利人:US GOV HEALTH & HUMAN SERV 摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.
专利号:US-8835658-B2 优先权日:2012-12-28 标 题:Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities 发明人:CHAN ALBERT SUN-CHI; FAN BAOMIN; WANG JUN; LIN CHENGYUAN; HUANG CHAO; YANG QINGJING; XU JIANBIN; BIAN ZHAOXIANG; LU AIPING; HU JUN 权利人:UNIV HONG KONG BAPTIST; UNIV YUNNAN NATIONALITIES 摘要:The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
专利号:US-11691135-B2 优先权日:2020-10-15 标 题:Synthesis of alkynones via carbonylative Sonogashira coupling reactions catalyzed by Pd(II)-N-Heterocyclic carbene-pyridine complexes 发明人:EL ALI BASSAM; MANSOUR WASEEM; FETTOUHI MOHAMMED 权利人:UNIV KING FAHD PET & MINERALS; SAUDI ARABIAN OIL CO 摘要:This disclosure relates to N-substituted Pd(II)-N-heterocyclic carbene-pyridine complexes, methods of preparing the complexes, and methods of using the complexes in Sonogashira coupling reactions.