CAS: 6853-87-8; (2R)-2-Amino-3-(Methylsulfinyl)Propanoic Acid

该化合物是一种非蛋白性氨基酸,其特征是其硫基功能组,该化合物因其作为生物活性分子开发的前体或中间体的作用,对有机合成和制药研究具有兴趣.甲基硫基物质会增强它的回活动性和选择性修改潜力,使其在不对称合成和药用化学应用中具有价值.其立体化学纯度(R-配置)确保了对应选择性反应的一致性.该化合物在受控条件下的稳定性以及与标准混合试剂的兼容性进一步增强了其在化和小分子衍生作用.对于需要高精度手性建筑块的研究应用来说是合适的.

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相似化合物

4740-94-7 32726-14-0 88547-35-7

上下游产品

CAS号1187-84-4 S-甲基-L-半胱氨酸 | CAS号56-41-7 L-丙氨酸

合成工艺路线路线简述

    📜S-甲基-L-半胱氨酸置于双氧水体系中,用 水 作为反应溶剂,化学反应 1.0H,以87%的收率获得产物s-甲基-L-半胱氨酸亚砜
    参考文献:叔丁基二甲基甲硅烷基化后,通过气相色谱-质谱法测定s-甲基-,S-丙基-和s-丙烯基-L-半胱氨酸亚砜.
    标题:叔丁基二甲基甲硅烷基化后,通过气相色谱-质谱法测定s-甲基-,S-丙基-和s-丙烯基-L-半胱氨酸亚砜.
    摘要:气相色谱-质谱法测定s-甲基-L-半胱氨酸亚砜(1),S-丙基-L-半胱氨酸亚砜(2)和s-丙烯基-L-半胱氨酸亚砜(3)描述了葱属中的化合物.目标氨基酸被转化为叔丁基二甲基甲硅烷基衍生物.产物在氨基和羧基以及另外的氧原子上被甲硅烷基化,并在非极性毛细管柱上分离.通过质谱法证实已经发生了三个叔丁基二甲基甲硅烷基的掺入,这给出了一个m / Z 302片段作为碱基峰(氨基酸侧链消除离子)和m / Z 436(1),464(2)或462(3)为主要峰(叔丁基官能团消除了离子),通过电子碰撞电离.在选定的离子监测下,分别在m / Z 436(1)和m / Z 464(2)下进行的1和2的检出限确定为每次进样0.3 Ng和1.8 Ng.为了从洋葱的溶剂提取物中(作为代表性的食物原料)洋葱中清除分析物,对样品溶液进行固相萃取.将来自sep-Pak C(18)柱的洗脱液应用于bond Elut Scx柱(h(+)形式),然后用0
    DOI:10.1021/jf020166E

    海关参考信息

    专利信息


    专利号:WO-2022103364-A1
    优先权日:2020-11-11
    标题 :Carbon nanoparticle synthesis method and use thereof for huvec cancer treatment
    发明人:KARIPER AFSIN
    权利人:ERCIYES UNIV
    摘要:The present invention relates to synthesis method of carbon nanoparticle solutions which can be produced in large quantities, used as carrier for drugs that are used in treatment process for cancer cells such as breast cancer (MCF-7) and human osteosarcoma (Saos-2) and which are also used for cancer treatment due to their ability to show cytotoxic effects against cancer cells in cell lines of human umbilical vein endothelial cells (HUVEC).

    专利号:US-9707201-B2
    优先权日:2013-07-15
    标 题:Allium extracts
    发明人:BENNETT NORMAN JOHN; RAMSEY EDWARD DALHOUSIE
    权利人:LEPTREX LTD
    摘要:Improvements in or relating to Allium extracts. In particular, improvements in or relating to extending the therapeutic half-life or duration of Allium extracts. The invention further relates to the synthesis of methyl methyl thiosulfinate in a mixture with varying molar or mass ratios depending on the reaction conditions, in particular from either methiin or alliin alone or a mixture of both. Methods of treatment methicillin-resistant Staphylococcus aureus are also provided. Also provided is a kit comprising methiin in a first container and alliin in a second container.

    专利号:US-3957760-A
    优先权日:1970-12-16
    标 题:Amino acid derivatives
    发明人:BODANSZKY MIKLOS
    权利人:SQUIBB & SONS INC
    摘要:New lactone intermediates useful in the synthesis of peptides are prepared by reacting an α-amino acid with an active carbonyl compound which forms a Schiff's base. The latter is treated with a condensing agent so that cyclization occurs and a lactone is formed from which a peptide may be produced by reaction with an amino acid ester and removal of the protecting groups.

    专利号:CN-118638765-A
    优先权日:2024-05-24
    标 题:Cystathionine beta lyase and application thereof in synthesis of thiosulfinate compounds

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807.

    合成参考文献


    参考文献:10.5281/zenodo.5794106
    摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
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