CAS: 635-53-0; 2-(Carboxymethoxy)Benzoic Acid

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chloroacetic acid ethyl ester methyl salicylate ethyl bromoacetate chloroacetic acid ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate 2-chlor°Carbonylmethoxy-benzoyl chloride 2-carboxymethoxy-5-chloro-benzoic acid acetatemethyl (2-methoxycarbonyl)phenoxyacetate

合成工艺路线路线简述

    📜水杨酸甲酯置于水,Potassium Carbonate,Sodium Hydroxide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 20.0H,反应生成 2-(羧基甲氧基)苯甲酸
    参考文献: Process For Preparing (E)-(5,6-Dihydro-1,4,2-Dioxazine-3-yl) (2-Hydroxyphenyl) Methanone O-Methyl Oxime[fr] Procédé De Préparation De O-Méthyl Oxime De (E)-(5,6-Dihydro-1,4,2-Dioxazin-3-yl) (2-Hydroxyphényl)Méthanone
    标题: Process For Preparing (E)-(5,6-Dihydro-1,4,2-Dioxazine-3-yl) (2-Hydroxyphenyl) Methanone O-Methyl Oxime[fr] Procédé De Préparation De O-Méthyl Oxime De (E)-(5,6-Dihydro-1,4,2-Dioxazin-3-yl) (2-Hydroxyphényl)Méthanone
    摘要:描述了一种制备(E)-(5,6-二氢-1,4,2-二噁嗪-3-基)(2-羟基苯基)甲酮o-甲基肟的方法,包括:(I)将苯并呋喃-3(2H)-酮o-甲基肟(1)与n-丁基亚硝酸酯和叔丁基亚硝酸酯中至少一种进行反应,在金属烷氧化物存在下形成(2Z,3Z)-2,3-苯并呋喃二酮o-3-甲基二肟(2)作为主要异构体;(II)将(2Z,3Z)-2,3-苯并呋喃二酮o-甲基二肟(2)与2-卤乙醇反应,形成(2Z,3Z)-苯并呋喃-2,3-二酮o2-(2-羟乙基)O3-甲基二肟(3);(Iii)将(2Z,3Z)-苯并呋喃-2,3-二酮o2-(2-羟乙基)O-甲基二肟(3)与酸反应,形成(E)-(5,6-二氢-1,4,2-二噁嗪-3-基)(2-羟基苯基)甲酮o-甲基肟(4).

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    专利信息


    专利号:US-8926801-B2
    优先权日:2009-01-16
    标题 :Methods of electrospray chemical synthesis and device for use therein
    发明人:REHMAN ATIQ
    权利人:REHMAN ATIQ; CANAM BIORES INC
    摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.

    专利号:US-6603025-B1
    优先权日:1999-11-16
    标题:Method of production of benzofuranone oximes
    发明人:LANTZSCH REINHARD; GAYER HERBERT; GERDES PETER; HUEBSCH WALTER; MULDER LUBBERTUS; GALLENKAMP BERND; DECKER MATTHIAS
    权利人:BAYER AG
    摘要:The present invention relates to a novel process for preparing known benzofuranone oximes, and to a novel process for preparing known benzofuranyl alkanoates which are used as intermediates in the synthesis sequence.

    专利号:CA-2749875-A1
    优先权日:2009-01-16
    标 题:Methods of electrospray chemical synthesis and device for use therein

    专利号:US-2012012453-A1
    优先权日:2009-01-16
    标题:Methods of electrospray chemical synthesis and device for use therein

    专利号:US-2015196889-A1
    优先权日:2009-01-16
    标 题:Methods of electrospray chemical synthesis

    专利号:WO-2010081236-A1
    优先权日:2009-01-16
    标 题:Methods of electrospray chemical synthesis and device for use therein

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review., 5(7), 1953
    摘要:K. Suzuki and K. Yamasaki, J. Inorg. Nucl. Chem. 24, 1093 (1962).
    参考文献:10.1021/jm011100y
    摘要:Liljebris C, Larsen SD, Ogg D, Palazuk BJ, Bleasdale JE. Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity. J Med Chem. 2002 Apr 25;45(9):1785–98. doi: 10.1021/jm011100y.
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