CAS: 6155-57-3; Sodium 3-Oxo-3H-Benzo[d]Isothiazol-2-Ide 1,1-Dioxide Dihydrate

专利信息

专利号:US-10022366-B2
优先权日:2013-04-23
标 题:Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
发明人：STINCHCOMB AUDRA L; GHOSH PRIYANKA
权利人:STINCHCOMB AUDRA L; GHOSH PRIYANKA; UNIV MARYLAND; UNIV KENTUCKY RES FOUND
摘要:Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.

专利号:US-2025296948-A1
优先权日:2022-12-07
标 题 :Synthesis of nucleoside derivatives
发明人：DAMMALAPATI VENKATA LAKSHMI NARASIMHA RAO; THATIPALLY SURESH; KENNOVIN GORDON
权利人:NuCana plc
摘要:This invention relates to a novel process for the preparation of 5-fluoro-2′-deoxyuridine-5′—O-[1-naphthyl (benzoxy-L-alaninyl)] phosphate (NUC-3373) and derivatives thereof. The NUC-3373 made according to this process is more stable than NUC-3373 made according to alternative processes.

专利号:EP-4630433-A1
优先权日:2022-12-07
标 题 :Synthesis of nucleoside derivative nuc-3373

专利号:ZA-200604876-B
优先权日:2003-12-18
标题:Synthesis of a polymorph of 4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride hydrate

专利号:KR-20060123436-A
优先权日:2003-12-18
标 题 :Synthesis of a polymorph of 4-amino-5-chlor0-2-methoxy-n-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride hydrate

专利号:WO-2024121527-A1
优先权日:2022-12-07
标题:Synthesis of nucleoside derivative nuc-3373