CAS: 6064-83-1; 2-(Phosphonooxy)Benzoic Acid

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CAS号69-72-7 水杨酸 | CAS号91746-64-4 1-hydroxy-4,5-b... | CAS号67-56-1 甲醇 | CAS号1441-87-8 2-羟基苯甲酰氯 | CAS号15247-35-5 trichloro(diphe... | CAS号19579-04-5 tetrachlorophen... | CAS号6099-41-8 2-dichlorophosp... | CAS号87799-86-8 bis-(2-carboxyp... | CAS号872274-23-2 2-phosphonooxy-... | CAS号69-72-7 水杨酸 | CAS号7664-38-2 磷酸

📜1-Hydroxy-4,5-Benzo-2,6-Dioxaphosphorinanone(3)-1-Oxide置于sodium Hydroxide体系中,化学反应生成 磷柳酸
参考文献:环状酰基磷酸(on)酸盐抑制肠杆菌p99 C类β-内酰胺酶的机制:返还拯救
标题:环状酰基磷酸(on)酸盐抑制肠杆菌p99 C类β-内酰胺酶的机制:返还拯救
摘要:如前所述 (Pratt,Rf; Hammar,Njj Am. Chem. Soc. 1998,120,3004.),1-羟基-4,5-苯并-2,6-二氧杂磷啉酮(3)-1-氧化物(水杨酰基环磷酸盐)以共价方式灭活阴沟肠杆菌 P99 的 C 类β-内酰胺酶.失活的酶慢慢恢复为活性形式.本文表明,再活化涉及再生水杨酰环状磷酸酯的再循环反应,而不是共价中间体的水解.因此,失活是活性位点的缓慢可逆共价修饰.抑制剂与失活酶的热力学解离常数为 0.16 Microm.用碱处理灭活的酶不会产生水杨酸,但在随后的酸水解后会产生一摩尔当量的赖氨酸丙氨酸.该结果证明水杨酰环状磷酸酯通过活性位点丝氨酸残基的(缓慢可逆的)磷酸化使酶失活.该结果与无环酰基磷酸酯的行为形成鲜明对比,后者通过酰化作用使 P99 β-内酰胺酶暂时失活(li,N.;pratt,Rfj Am. Chem. Soc. 1998,120
DOI:10.1021/ja011094V

专利信息

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:AU-2022276509-A1
优先权日:2021-05-20
标题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-4778805-A
优先权日:1987-06-18
标题:4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis
发明人：ADAMS JULIAN; GUINDON YVAN; BELANGER PATRICE C; BELLEY MICHEL L; ROKACH JOSHUA
权利人:MERCK FROSST CANADA
摘要:4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##

专利号:WO-2022246227-A1
优先权日:2021-05-20
标 题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms