CAS: 5453-80-5; 5-Norbornene-2-Carboxaldehyde

相似化合物

120-74-1 6203-08-3 95-11-4

上下游产品

二聚环戊二烯 Bi(Cyclopentadiene) 77-73-6

N-Phenyl-N-Hydroxybicyclo[2.2.1]Hept-5-Ene-2-Carboxamide置于lithium Aluminium Tetrahydride,溶剂黄146体系中,用 四氢呋喃 作为反应溶剂,化学反应 5.0H,以87%的收率获得产物5-降冰片烯-2-甲醛
参考文献:与n-羟基-N-苯基丙烯酰胺的对映选择性diels-Alder反应.
标题:与n-羟基-N-苯基丙烯酰胺的对映选择性diels-Alder反应.
摘要:[反应:见正文]研究了使用异羟肟酸作为路易斯酸催化的对映选择性diels-Alder反应的模板.通过将光学纯的联萘酚与3当量的三甲基铝混合而制得的非常简单的手性路易斯酸,可在0oc以高收率(> 96%)催化n-羟基-N-苯基丙烯酰胺与环戊二烯的[4 + 2]环加成反应,并且具有相当好的对映选择性(91%ee).产物向相应的醇或醛的容易转化使得异羟肟酸中间体特别有用.
DOI:10.1021/ol025799T

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4837327-A
优先权日:1987-07-13
标 题 :Process for nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-6255424-B1
优先权日:1997-11-25
标 题:Dendritic polymers and convergent method of synthesis
发明人：KNAUSS DANIEL M
权利人:COLORADO SCHOOL OF MINES
摘要:A convergent process for synthesizing dendritic polymers typically having an average of three or more generations of branching and a narrow polydispersity. Precursor segments with living ends are coupled via a coupling agent to form branched units, each unit having a single living end. Further reaction with the coupling agent results in formation of a dendritic structure. Reaction of the coupling agent is controlled, such as by slow addition to the reaction mixture over an extended time, to promote development of the dendritic structure. The coupling agent typically has at least two functional groups capable of reacting with the living ends in the reaction mixture. One of the groups is capable of reacting with a living end in an addition reaction such as a vinyl addition, ring opening, or group transfer reaction. Optionally, a monomer can be added with the coupling agent to form longer branches. The structures may be terminated with a suitable functional group or with a linear polymer chain. One or more of the dendritic structures may be incorporated into a larger molecule.

专利号:US-4999429-A
优先权日:1989-01-09
标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries